PMID: 9427985Jan 15, 1998Paper

Midterm reversible failure in trabeculectomies with adjunctive mitomycin-C

Ophthalmic Surgery and Lasers
N KasaharaR J Simmons

Abstract

Trabeculectomies usually fail early (< 21 days) or late (> 6 months) when no antifibrotic agent is used. Failure is uncommon during the midterm period, between 3 weeks and 6 months. The purpose of this study is to verify the incidence of failure of trabeculectomies with mitomycin-C (MMC) during the midterm period and to evaluate the safety and efficacy of laser suture lysis (LSL) for reversing it. The authors reviewed the records of 130 consecutive patients who underwent trabeculectomy with adjunctive MMC. Fourteen patients (15 eyes) had increased intraocular pressure (IOP), between 21 and 185 days (median 41 days). LSL was effective in decreasing the IOP to acceptable levels in 10 (66.6%) of the 15 eyes. No complications related to LSL were noticed. The reversibility of midterm failure seems to be a unique feature of trabeculectomies with MMC.

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