Midterm Survival and Quality of Life After Extent II Thoracoabdominal Aortic Repair in Marfan Syndrome

The Annals of Thoracic Surgery
Ravi K GhantaJoseph S Coselli

Abstract

Pathologic conditions of the aorta remain a major source of morbidity and mortality for patients with Marfan syndrome (MFS). Extensive thoracoabdominal aortic aneurysm (TAAA) repair can prevent aortic catastrophe but carries substantial risk of perioperative adverse events. We evaluated midterm survival and quality of life (QoL) after contemporary Crawford extent II TAAA repair in patients with MFS. From 2004 to 2010, 49 consecutive patients with MFS (mean age, 43.4 ± 12.0 years) underwent extent II TAAA repair (41 elective and 8 urgent/emergent procedures) with intercostal reimplantation. Thirty-six patients (73%) had aorta-related symptoms, and 45 (92%) had distal aortic dissection. Operative adjuncts included cerebrospinal fluid drainage (n = 47 [96%]), left heart bypass (n = 46 [94%]), and cold renal perfusion (n = 47 [96%]). Kaplan-Meier survival analysis was performed. QoL was assessed in 24 patients with a 12-item survey (12-Item Short Form Health Survey version 2 [SF-12v2]) a median of 5.3 (interquartile range [IQR], 4.0-7.9) years postoperatively. QoL data were normalized and compared with data from the general population. There were no operative deaths, strokes, paraparesis, or paraplegia. Two patients (4%) had perman...Continue Reading

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Citations

Feb 24, 2016·The Journal of Thoracic and Cardiovascular Surgery·Joseph S CoselliTodd K Rosengart
Apr 30, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Florian Schoenhoff, Thierry Carrel
Jun 27, 2018·The Journal of Cardiovascular Surgery·Giovanni TinelliStéphan Haulon
Dec 2, 2020·Health and Quality of Life Outcomes·Thy Thy VanemCecilie Røe
Mar 25, 2019·The Journal of Thoracic and Cardiovascular Surgery·Joseph S CoselliScott A LeMaire
Sep 17, 2017·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Paula R KeschenauMichael J Jacobs

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