MIF Gene Polymorphism rs755622 Is Associated With Coronary Artery Disease and Severity of Coronary Lesions in a Chinese Kazakh Population: A Case-Control Study

Medicine
Jun-Yi LuoYi-Ning Yang

Abstract

Inflammation plays an important role in the pathogenesis of atherosclerosis. Recent studies indicate that macrophage migration inhibitory factor (MIF) is a potent proinflammatory cytokine which mediates the inflammatory process during atherosclerosis. The polymorphism of MIF gene (rs755622 [-173G/C], rs1007888, and rs2096525) were genotyped by TaqMan single nucleotide polymorphism (SNP) genotyping assay in 320 patients with coronary artery disease (CAD) and 603 controls in a Chinese Kazakh population. Coronary angiography was performed on all CAD patients and Gensini score was used to assess the severity of coronary artery lesions. The frequency of the CC genotype and C allele of rs755622 were significantly higher in CAD patients than that in control subjects (8.4% vs. 5.1%, P < 0.001, 30.3% vs. 22.1%, P < 0.001, respectively). Multivariate logistic regression analysis showed that individuals with CC genotype or C allele had a higher risk for CAD (CC genotype vs. GG genotype, OR = 2.224, 95% CI, 1.239-3.992, P = 0.007, and C allele vs. G allele, OR = 1.473, 95% CI, 1.156-1.876, P = 0.002, respectively). Moreover, CAD patients with rs755622 C allele (CC + CG genotype) have higher levels of Gensini score when compared to C allele...Continue Reading

References

Sep 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G K HanssonS Stemme
Jan 6, 1999·Controlled Clinical Trials·W D Dupont, W D Plummer
Mar 6, 2002·Circulation·Peter LibbyAttilio Maseri
Mar 13, 2002·Circulation·Johann W AuerBernd Eber
Feb 7, 2003·Journal of the American College of Cardiology·Raymond J GibbonsUNKNOWN American Heart Association Task Force on practice guidelines (Committee on the Management of Patients With Chronic Stable An
Mar 26, 2008·Circulation·Alma ZerneckeChristian Weber
Apr 4, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Andreas SchoberChristian Weber
Oct 8, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Leilani L Santos, Eric F Morand
Jan 27, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Irina P TereshchenkoMartin Petrek
Jun 13, 2009·Current Pharmaceutical Design·Jun Nishihira, Keiichi Mitsuyama
Aug 15, 2009·Trends in Cardiovascular Medicine·Heidi NoelsChristian Weber
Jul 8, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Lei WangBao-Zhu Wang
Mar 23, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christoph SinningStefan Blankenberg
Jun 1, 2013·Arthritis Research & Therapy·Fang-Fang WangLiang-Jing Lu
Oct 8, 2013·Journal of the American Heart Association·William ChanAnthony M Dart
Nov 7, 2013·Investigative Ophthalmology & Visual Science·Chunxia ZhangPeizeng Yang
Aug 12, 2014·Journal of Immunology Research·Emmanuel Valdés-AlvaradoJorgé Ramón Padilla-Gutiérrez
Nov 6, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Daniel Medeiros MoreiraCarlos Antonio Mascia Gottschall

❮ Previous
Next ❯

Citations

Jan 16, 2017·Journal of Molecular and Cellular Cardiology·Jun-Yi LuoYi-Ning Yang
Jun 1, 2017·Expert Opinion on Therapeutic Targets·Pathricia V TilstamRichard Bucala
May 11, 2018·BioMed Research International·Ye-Shun WuChun Yang
Jan 21, 2021·Pharmacogenomics and Personalized Medicine·Dongyu ChuoYuze Chen

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

Power and Sample Size
Haploview
SPSS
Sequence Detection Systems automation controller

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.