PMID: 39665Sep 1, 1979

MIF-I and postsynaptic receptor sites for dopamine

Brain Research Bulletin
R M KostrzewaF P Bymaster

Abstract

In an attempt to determine the mechanism by which the tripeptide l-prolyl-l-leucyl-glycine amide (PLG, MIF-I) exerts its antiparkinsonian effect, the action of this substance on various postsynaptic components of striatal dopaminergic nerves was studied. It was shown that injection of rats with MIF-I (1 mg/kg, IPX5, 24 hr intervals) did not alter tyrosine hydroxylase, dopa decarboxylase, choline acetyltransferase and glutamic acid decarboxylase activities in the striatum under the conditions tested. The activities of adenylate cyclase, dopamine-stimulated adenylate cyclase, and guanylate cyclase were not altered in vitro by various concentrations of MIF-I (0.1 to 1000 micrometer), although VIP and neurotensin had some effect. Also the rate of uptake of 3H-dopamine by rat striatal synaptosomes was unchanged, as was the binding of 3H-dopamine and 3H-spiperone to beef caudate membranes. This series of studies indicates that MIF-I does not act directly on the striatal dopamine postsynaptic receptor under the conditions tested, although it is possible that MIF-I could act indirectly at this or another site in vivo by releasing or activating some other factor.

References

Nov 1, 1975·Pharmacology, Biochemistry, and Behavior·R M KostrzewaM A Spirtes
Jan 1, 1976·Pharmacology, Biochemistry, and Behavior·R M KostrzewaT H Joh
Aug 1, 1977·Journal of Neurochemistry·M HofmannK Kumakura
Sep 1, 1978·Pharmacology, Biochemistry, and Behavior·R M KostrzewaS K Sobrian
Jun 22, 1972·Brain Research·F Lamprecht, J T Coyle
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J W KebabianP Greengard
Oct 1, 1972·Journal of Neurochemistry·V Glover, D P Green
Nov 23, 1973·Science·E FriedmanS Gershon
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Jul 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·N P PlotnikoffA V Schally

Citations

Apr 12, 1989·European Journal of Pharmacology·R M KostrzewaA J Kastin
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·T K von AlmenR D Olson
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·M V Graf, A J Kastin
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·R M Kostrzewa
Jan 1, 1982·Pharmacology & Therapeutics·D H Versteeg
Jan 1, 1980·Peptides·S L Dickinson, P Slater

Related Concepts

Adenylate Cyclase
Metazoa
Lentiform Nucleus Structure
Intropin
Guanylate Cyclase
MSH Release-Inhibiting Hormone
Dopamine Receptor
Spiperone
Synapses
Rats, Laboratory

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