Mifepristone: a potential clinical agent based on its anti-progesterone and anti-glucocorticoid properties

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Yayi SunZhiying Hu


Nowadays, unwanted pregnancy is a major globe tragedy for millions of women, associated with significant direct and indirect costs, no matter for individuals or society. The progesterone receptor antagonist steroid, mifepristone has been widely and effectively using throughout the world for medical abortion, but to a lesser extent for emergency contraception. In this review, we hope to explore the role of mifepristone as a contraceptive, particularly for emergency contraception. Studies of mifepristone have also been expanding to the fields of endometriosis and uterine fibroids. Furthermore, this initially considered reproductive medicine has been investigated in some psychotic diseases and various disorders of hypercortisolism, because of its glucocorticoid receptor antagonism. Mifepristone was approved suitable for patients with hyperglycemia secondary to Cushing's syndrome by the United States Food and Drug Administration (FDA) in 2012. The aim of this article is to review published reports on the anti-progesterone and anti-glucocorticoid properties of mifepristone as a clinical agent. There is a new insight into systematically describing and evaluating the potential efficiency of mifepristone administrated in the field of e...Continue Reading


Feb 28, 2002·Molecular and Cellular Neurosciences·Hanne RasmussenChristian Vannier
Sep 6, 2002·Journal of Molecular Neuroscience : MN·Joseph K BelanoffAlan F Schatzberg
Sep 11, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ai H LiaoXi R Wu
Apr 22, 2006·Contraception·Nathalie KappPhillip Stubblefield
Dec 13, 2006·Contraception·Kaiyan PeiHeng Zhao
Apr 17, 2008·The Journal of Clinical Endocrinology and Metabolism·B M K BillerM Boscaro
Sep 17, 2008·Reproductive Health Matters·Kristina Gemzell-Danielsson, Sujata Lalitkumar
Sep 12, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yanina RevsinMelly S Oitzl
Nov 26, 2008·American Journal of Obstetrics and Gynecology·Mukta AgarwalDeepali Srivastava
Nov 6, 2009·Advances in Therapy·Coleman GrossJoseph K Belanoff
Dec 17, 2009·Contraception·Eric A Schaff
Jan 28, 2010·Expert Opinion on Pharmacotherapy·Annie Im, Leonard J Appleman
Mar 13, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Suman LalNutan Agarwal
May 27, 2010·Obstetrics and Gynecology·Kelly ClelandHaoping Zhu
Jul 24, 2010·Archives of Gynecology and Obstetrics·Krishna DahiyaSmiti Nanda
Apr 13, 2011·Taiwanese Journal of Obstetrics & Gynecology·Yiu-Tai LiTsung-Cheng Kuo
Jun 23, 2011·Journal of Clinical Psychopharmacology·Christine M BlaseyRobert L Roe
Jul 12, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Qiu-ju ChenUNKNOWN EBM-CONNECT Collaboration
Aug 30, 2011·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Anibal FaúndesUNKNOWN International Federation of Gynecology and Obstetrics
Dec 14, 2011·Clinical Therapeutics·Ashley R Richardson, Fraidy N Maltz
Mar 15, 2012·Molecular and Cellular Endocrinology·Nathalie Chabbert-BuffetPhilippe Bouchard
May 1, 2012·Current Opinion in Endocrinology, Diabetes, and Obesity·Frederic CastinettiBernard Conte-Devolx
Aug 18, 2012·Contraception·Elizabeth G RaymondBeverly Winikoff
Nov 2, 2012·Contraception·Kristina Gemzell-DanielssonLalitkumar P G L
Feb 7, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·P G L LalitkumarKristina Gemzell-Danielsson
Feb 26, 2013·Pharmacotherapy·Farah H Morgan, Marc J Laufgraben
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