Mifepristone (RU38486) influences the core temperature response of term pregnant rats to intraperitoneal lipopolysaccharide

Experimental Physiology
Sherry L Moore, James E Fewell

Abstract

Pregnancy alters the cytokine, prostanoid and core temperature responses of rats to infectious stimuli at a time when blood levels of the endogenous glucocorticoid corticosterone are elevated. Given that glucocorticoids attenuate bacterial pyrogen-induced fever in rats, the present experiments were carried out to test the hypothesis that administration of RU38486, a glucocorticoid type II receptor antagonist, would restore the febrile response to E. coli lipopolysaccharide (LPS) in pregnant rats on day 21 of gestation. Pregnant rats were randomly allocated to one of four experimental groups depending upon whether they received RU38486 (20 mg kg(-1) intragastric) or vehicle followed by E. coli LPS (160 microg kg(-1)i.p.; a minimal dose that elicits maximal febrile response in non-pregnant rats) or vehicle. Basal core temperature was not altered by intragastric administration of RU38486 or vehicle. Following intragastric administration of vehicle, intraperitoneal administration of E. coli LPS produced a significant hypothermia with latency, duration and magnitude of 0.5 h, 2 h and -1.3 degrees C, respectively. Following intragastric administration of RU38486, however, intraperitoneal administration of E. coli LPS elicited only a ...Continue Reading

References

Jun 1, 1975·The Journal of Endocrinology·J P DupouyS Magre
Nov 6, 1975·Nature·T NakayamaN Ishizuka
Nov 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·H BesedovskyJ Müller
Sep 1, 1985·Journal of Steroid Biochemistry·D GagneD Philibert
Apr 1, 1970·Endocrinology·M E FreemanE K Inskeep
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·F HirataJ Axelrod
Sep 1, 1996·Journal of Applied Physiology·K M Stobie-Hayes, J E Fewell
Sep 18, 1997·Journal of Applied Physiology·H L Eliason, J E Fewell
Jun 18, 1998·Annals of the New York Academy of Sciences·A V TurnbullC Rivier
Jan 13, 2000·Proceedings of the Society for Experimental Biology and Medicine·S RivestN Laflamme
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kyoko Imai-MatsumuraYasuyoshi Watanabe
May 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paula J BruntonJohn A Russell

❮ Previous
Next ❯

Citations

Jan 14, 2012·Journal of Molecular Cell Biology·Shuangtao MaZhiming Zhu
Jul 18, 2006·Physiology & Behavior·Maisie TsangSherry L Moore
May 17, 2015·American Journal of Obstetrics and Gynecology·Valeria Dell'OvoLaura Goetzl
Apr 15, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brent N Alexander, James E Fewell
Jul 30, 2010·Stress : the International Journal on the Biology of Stress·María C Rodríguez-GalánSilvia G Correa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.