Might limiting liquid nicotine concentration result in more toxic electronic cigarette aerosols?

Tobacco Control
Soha TalihAlan L Shihadeh

Abstract

Some jurisdictions have instituted limits on electronic cigarette (ECIG) liquid nicotine concentration, in an effort to control ECIG nicotine yield, and others are considering following suit. Because ECIG nicotine yield is proportional to the product of liquid nicotine concentration (milligram per millilitre) and device power (watts) regulations that limit liquid nicotine concentration may drive users to adopt higher wattage devices to obtain a desired nicotine yield. In this study we investigated, under various hypothetical regulatory limits on ECIG liquid nicotine concentration, a scenario in which a user of a common ECIG device (SMOK TF-N2) seeks to obtain in 15 puffs the nicotine emissions equivalent to one combustible cigarette (ie, 1.8 mg). We measured total aerosol and carbonyl compound (CC) yields in 15 puffs as a function of power (15-80 W) while all else was held constant. The estimated nicotine concentration needed to achieve combustible cigarette-like nicotine yield at each power level was then computed based on the measured liquid consumption. We found that for a constant nicotine yield of 1.8 mg, reducing the liquid nicotine concentration resulted in greater amount of liquid aerosolised (p<0.01) and greater CC emi...Continue Reading

References

Oct 7, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M Al RashidiN A Saliba
Sep 3, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Alan Shihadeh, Thomas Eissenberg
Sep 18, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Alexa A LopezThomas Eissenberg
May 29, 2016·Psychopharmacology·Lynne E DawkinsOlivia Corcoran
Sep 25, 2017·Chemical Research in Toxicology·Soha TalihAlan Shihadeh
Oct 25, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Leon KosmiderLynne E Dawkins
Nov 27, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Rola SalmanAlan Shihadeh
Feb 13, 2019·Tobacco Control·Soha TalihAlan Shihadeh
Mar 3, 2019·International Journal of Environmental Research and Public Health·Jorien SmetsDinska Van Gucht
Mar 27, 2019·Journal of American College Health : J of ACH·Melinda IckesRamakanth Kavuluru

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Citations

Aug 28, 2020·Expert Opinion on Drug Delivery·Vinit V GholapMatthew S Halquist
Apr 3, 2021·Addictive Behaviors·Alayna P TackettTheodore L Wagener

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