PMID: 20135752Feb 6, 2010Paper

Might platelet-leucocyte complexes be playing a role in major vascular involvement of Behçet's disease? A comparative study

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Gülsüm E PamukNecati Cakir

Abstract

We determined platelet-leucocyte complexes, which play roles in the thrombosis-inflammation relationship, in Behçet's disease patients with and without major vascular involvement (MVI) and in healthy controls. We included 36 Behçet's disease patients (22 male, 14 female, mean age: 34.4 +/- 8.3 years) and 20 healthy individuals (14 male, six female, mean age: 31.8 +/- 4.4 years). Whole blood count, CRP and ESR were determined in both groups. Clinical data about the patients were obtained from medical charts. Individuals with hypertension, diabetes, coronary artery disease, and smokers were excluded. Behçet's disease patients with MVI were taken as a separate group (8 male, 5 female, mean age: 37 +/- 8 years). MVI was defined as the presence of pulmonary arterial aneurysm, deep venous thrombosis, vena cava inferior or superior thrombosis, or venous sinus thrombosis. Flow cytometry was used to determine platelet-monocyte complexes (PMC), platelet-neutrophil complexes (PNC), basal and adenosine diphosphate (ADP)-stimulated platelet CD62P expression. Behçet's disease patients with MVI had significantly higher PNC than Behçet's disease patients without MVI and healthy controls (P values = 0.01). PMC levels in Behçet's disease patient...Continue Reading

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Citations

Jul 5, 2011·Archives of Medical Research·Meriam MessediFatma Ayedi
Jul 22, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Hulya UzkeserAyse Carlioglu
Dec 3, 2010·Current Opinion in Rheumatology

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