Abstract
We determined platelet-leucocyte complexes, which play roles in the thrombosis-inflammation relationship, in Behçet's disease patients with and without major vascular involvement (MVI) and in healthy controls. We included 36 Behçet's disease patients (22 male, 14 female, mean age: 34.4 +/- 8.3 years) and 20 healthy individuals (14 male, six female, mean age: 31.8 +/- 4.4 years). Whole blood count, CRP and ESR were determined in both groups. Clinical data about the patients were obtained from medical charts. Individuals with hypertension, diabetes, coronary artery disease, and smokers were excluded. Behçet's disease patients with MVI were taken as a separate group (8 male, 5 female, mean age: 37 +/- 8 years). MVI was defined as the presence of pulmonary arterial aneurysm, deep venous thrombosis, vena cava inferior or superior thrombosis, or venous sinus thrombosis. Flow cytometry was used to determine platelet-monocyte complexes (PMC), platelet-neutrophil complexes (PNC), basal and adenosine diphosphate (ADP)-stimulated platelet CD62P expression. Behçet's disease patients with MVI had significantly higher PNC than Behçet's disease patients without MVI and healthy controls (P values = 0.01). PMC levels in Behçet's disease patient...Continue Reading
References
Mar 1, 1987·The Journal of Clinical Investigation·R L Silverstein, R L Nachman
Oct 1, 1995·Seminars in Cell Biology·D E LorantS M Prescott
Jan 23, 1999·Current Opinion in Rheumatology·H YaziciV Hamuryudan
Sep 1, 1999·Current Opinion in Hematology·A D Michelson, M I Furman
Oct 21, 1999·The New England Journal of Medicine·T SakaneG Inaba
Jan 11, 2000·Annals of the Rheumatic Diseases·E HaznedarogluS V Dündar
Apr 12, 2000·Histopathology·M KobayashiY Nimura
Nov 13, 2001·British Journal of Haematology·J E JosephS J Machin
Apr 18, 2002·Thrombosis Research·Sedat KirazMeral Calgüneri
Jan 25, 2003·Medicine·Emire Kural-SeyahiHasan Yazici
Feb 20, 2003·Thrombosis Research·Torben VillmowAxel C Matzdorff
Aug 16, 2003·Advances in Experimental Medicine and Biology·H NakanoS Ozaki
Oct 18, 2003·Joint, Bone, Spine : Revue Du Rhumatisme·Aline TohméElie Ghayad
Dec 16, 2003·Current Opinion in Rheumatology·Sebahattin YurdakulHasan Yazici
Mar 9, 2004·Rheumatology International·S Ercan TuncAfig Huseyinov
Jun 24, 2004·Thrombosis and Haemostasis·Aya ShibamiyaTakatoshi Koyama
Dec 18, 2004·Current Opinion in Rheumatology·Kenneth T CalamiaMelike Melikoglu
Aug 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·D J H McCabeM M Brown
Sep 30, 2005·Mediators of Inflammation·Yusuf TurkozOzgür Ilhan
Aug 31, 2006·American Journal of Hematology·Gülsüm E PamukAhmet Tezel
Sep 27, 2006·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Servet AkarFatos Onen
May 3, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Gülsüm Emel PamukNecati Cakir
Aug 28, 2007·Thrombosis and Haemostasis·Jihwa ChungTakatoshi Koyama
Mar 12, 2008·Pathophysiology of Haemostasis and Thrombosis·M MartínezA Vayá
Citations
Apr 25, 2012·ISRN Pharmacology·M B Owlia, G Mehrpoor
Jul 5, 2011·Archives of Medical Research·Meriam MessediFatma Ayedi
Jul 22, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Hulya UzkeserAyse Carlioglu
Apr 15, 2016·Platelets·Yuji TakedaIchiro Wakabayashi
Jun 15, 2013·Angiology·Ozlem EkizSait Demirkol
Apr 12, 2011·Phlebology·T KotsisV Andrikopoulos
Oct 23, 2020·Orphanet Journal of Rare Diseases·Maryam MasoumiJavad Balasi
Feb 24, 2021·BMC Immunology·Linlin ChengYongzhe Li
Apr 21, 2021·Reumatismo·A S HammamiS Ouali
Dec 3, 2010·Current Opinion in Rheumatology