Migraine and Autonomic Dysfunction: Which Is the Horse and Which Is the Jockey?

Current Pain and Headache Reports
Mitchell G Miglis

Abstract

Symptoms of autonomic dysfunction are common in patients with migraine, both during and between migraine attacks. Studies evaluating objective autonomic testing in patients have found significant, though somewhat conflicting results. The purposes of this review are to summarize and interpret the key findings of these studies, including those evaluating heart rate variability, autonomic reflex testing, and functional imaging in patients with migraine. The neuroanatomy of the central autonomic network as it relates to migraine is also reviewed. Several studies have evaluated autonomic balance in migraineurs, with conflicting results on the magnitude of sympathetic versus parasympathetic dysfunction. Most studies demonstrate sympathetic impairment, with a lesser degree of parasympathetic impairment. Three trends have emerged: (1) migraine with aura tends to produce more significant autonomic dysfunction than migraine without aura, (2) sympathetic impairment is more common than parasympathetic impairment, and (3) sympathetic impairment is common in the interictal period, with increased sympathetic responsiveness during the ictal period, suggesting adrenoreceptor hypersensitivity.

Associated Clinical Trials

Nov 13, 2020·Prof. Christian Wöber, MD

References

Dec 1, 1989·Cephalalgia : an International Journal of Headache·M BoccuniF Cangi
Oct 1, 1986·Headache·H Havanka-Kanniainen
Sep 1, 1984·Archives of Neurology·F GotohS Gomi
Nov 1, 1993·Headache·T PogacnikT Kiauta
Jul 22, 1998·Epilepsia·S C Schachter, C B Saper
Dec 23, 2004·Headache·A MosekP A Low
Apr 12, 2006·Neurology·R D ThijsJ G van Dijk
May 12, 2006·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·E E Benarroch
Mar 14, 2007·Mayo Clinic Proceedings·Mark J ThiebenPhillip A Low
Dec 7, 2007·Headache·Marie DenuelleGilles Geraud
Mar 31, 2010·Seminars in Neurology·F Michael Cutrer
Jul 24, 2010·Headache·Stefan Evers
Sep 8, 2010·Cephalalgia : an International Journal of Headache·Ramesh K Khurana, Lindsay Eisenberg
Aug 19, 2011·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·David CurfmanThomas C Chelimsky
Jul 16, 2013·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Catello VollonoGiacomo Della Marca
May 13, 2015·Cephalalgia : an International Journal of Headache·Julian KoenigJulian F Thayer
Jan 12, 2016·Current Neurology and Neuroscience Reports·Shuhan Zhu, Michael J Marmura
May 12, 2016·The Journal of Headache and Pain·Oleg V MamontovAlexei A Kamshilin

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Citations

Oct 27, 2018·Current Treatment Options in Gastroenterology·Elliot S YuThangam Venkatesan
Apr 3, 2019·Annals of Neurology·Nasim MalekiJoseph J Locascio
Sep 25, 2019·Headache·Rebecca Wig, Christopher B Oakley
Sep 21, 2019·Current Pharmaceutical Design·George Anderson
Jan 3, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Melissa M CortezCorey L Campbell
Oct 12, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Mehmet Tolga DogruHayrunnisa Bolay
Mar 14, 2020·Cephalalgia : an International Journal of Headache·Noemi MeylakhLuke A Henderson
Mar 19, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ilmari PyykköVinaya Manchaiah
Jun 5, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K M LinstraG M Terwindt
Jun 26, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Asuman Celikbilek
Mar 16, 2019·Current Pain and Headache Reports·Karissa N Arca, Rashmi B Halker Singh
Jan 15, 2020·Expert Review of Neurotherapeutics·Rebecca Erwin WellsZev Schuman-Olivier
Apr 8, 2020·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Xiaolei ShiAneta Wieczorek
Jan 2, 2020·Surgical Neurology International·Luxwell JokonyaGift Ngwende
Nov 18, 2020·Cephalalgia : an International Journal of Headache·Cédric GollionVincent Larrue
Nov 29, 2020·European Journal of Ophthalmology·Merve Beyza YildizYılmaz Çetinkaya
Feb 10, 2021·Cephalalgia : an International Journal of Headache·Inna E TchivilevaGary D Slade
Dec 8, 2020·Frontiers in Human Neuroscience·Giuseppina PilloniLeigh E Charvet
Apr 13, 2021·The International Journal of Neuroscience·Majed Al-HayaniBadrah Alghamdi
Jun 1, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rita De SanctisArmando Santoro
Jun 29, 2021·Frontiers in Neurology·Eduardo Rivera-MancillaAntoinette MaassenVanDenBrink
Jul 29, 2021·JMIR Formative Research·Sigrid Hegna IngvaldsenAnker Stubberud
Oct 29, 2021·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Iain MaysJonathan Egan
Nov 18, 2021·Cephalalgia : an International Journal of Headache·Mansoureh ToghaSeyedeh Melika Hashemi

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