Migraine and traumatic brain injury: a cohort study in Taiwan

BMJ Open
Qing-Rui WangChieh-Hsin Wu

Abstract

Traumatic brain injury is now a major contributor to the global healthcare burden. Migraine is another debilitating disease with a global health impact. While most researchers agree that traumatic brain injury is a risk factor for migraine, whether migraine is a risk factor for traumatic brain injury still remains under debate. We therefore aimed to investigate whether migraine was a risk factor for developing traumatic brain injury. Retrospective population-based cohort study. Data for people who had been diagnosed with migraine were retrieved from Taiwan's National Health Insurance Research Database. We identified 7267 patients with newly diagnosed migraine during 1996-2010. The migraineurs to non-migraineurs ratio was set at 1:4 to enhance the power of statistical tests. We used multivariate Cox proportional hazard regression models to assess the effects of migraines on the risk of traumatic brain injury after adjusting for potential confounders. The overall traumatic brain injury risk was 1.78 times greater in the migraine group compared with the non-migraine group after controlling for covariates. Additionally, patients with previous diagnoses of alcohol-attributed disease, mental disorders and diabetes mellitus had a sign...Continue Reading

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Citations

Aug 11, 2020·Journal of the Chinese Medical Association : JCMA·Wei-Hsin Yuan, Shuu-Jiun Wang
Jun 9, 2020·Applied Bionics and Biomechanics·Manon Limousis-Gayda, Rami Hashish
Aug 20, 2021·Journal of Neurotrauma·Sung-Joon ChoAylin Y Reid

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