Migraine Frequency Decrease Following Prolonged Medical Cannabis Treatment: A Cross-Sectional Study

Brain Sciences
Joshua AviramDavid Meiri

Abstract

Medical cannabis (MC) treatment for migraine is practically emerging, although sufficient clinical data are not available for this indication. This cross-sectional questionnaire-based study aimed to investigate the associations between phytocannabinoid treatment and migraine frequency. Participants were migraine patients licensed for MC treatment. Data included self-reported questionnaires and MC treatment features. Patients were retrospectively classified as responders vs. non-responders (≥50% vs. <50% decrease in monthly migraine attacks frequency following MC treatment initiation, respectively). Comparative statistics evaluated differences between these two subgroups. A total of 145 patients (97 females, 67%) with a median MC treatment duration of three years were analyzed. Compared to non-responders, responders (n = 89, 61%) reported lower current migraine disability and lower negative impact, and lower rates of opioid and triptan consumption. Subgroup analysis demonstrated that responders consumed higher doses of the phytocannabinoid ms_373_15c and lower doses of the phytocannabinoid ms_331_18d (3.40 95% CI (1.10 to 12.00); p < 0.01 and 0.22 95% CI (0.05-0.72); p < 0.05, respectively). These findings indicate that MC resul...Continue Reading

References

Dec 28, 1999·Brain : a Journal of Neurology·P Tfelt-HansenP J Goadsby
Oct 4, 2005·Life Sciences·Mahmoud A Elsohly, Desmond Slade
Nov 23, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paola SarchielliPaolo Calabresi
Mar 25, 2008·Neurobiology of Disease·L M CupiniM Maccarrone
Jul 2, 2010·The New England Journal of Medicine·Elizabeth Loder
Sep 8, 2010·Cephalalgia : an International Journal of Headache·Min YangMark Kosinski
Feb 19, 2011·The Journal of Headache and Pain·Rosaria GrecoCristina Tassorelli
Jul 14, 2011·British Journal of Pharmacology·Ethan B Russo
Mar 1, 2012·Drug Testing and Analysis·A Hazekamp, J T Fischedick
May 2, 2013·The Cochrane Database of Systematic Reviews·Sheena Derry, R Andrew Moore
Apr 17, 2015·Headache·Werner J Becker
Aug 8, 2015·Continuum : Lifelong Learning in Neurology·Stephen D Silberstein
Jan 11, 2016·Pharmacotherapy·Danielle N RhyneLaura M Borgelt
Jun 17, 2010·Pharmaceuticals·Arpad Pardutz, Jean Schoenen
Jun 1, 2016·Cannabis and Cannabinoid Research·Michelle SextonLaurie K Mischley
Sep 14, 2017·Journal of the American Medical Directors Association·Sarah S StithAnthony P Reeve
Nov 8, 2017·European Journal of Pharmacology·Ram KandasamyMichael M Morgan
Jan 6, 2018·The American Journal of Psychiatry·Dennis McCarty
Apr 4, 2018·JAMA Internal Medicine·Ashley C BradfordGrace Bagwell Adams
Nov 10, 2018·The Journal of Headache and Pain·Casper Emil ChristensenMessoud Ashina
Sep 30, 2019·Neurologic Clinics·Rebecca C BurchRichard B Lipton
Nov 13, 2019·The Journal of Pain : Official Journal of the American Pain Society·Carrie CuttlerRebecca M Craft
Feb 6, 2020·Rambam Maimonides Medical Journal·Jeffrey Y HergenratherDavid Meiri

❮ Previous
Next ❯

Citations

Feb 26, 2021·Current Pain and Headache Reports·Laszlo L MechtlerVincent H Bargnes
Nov 14, 2020·Brain Sciences·Marco Colizzi, Sagnik Bhattacharyya
Jun 26, 2021·Journal of Ethnopharmacology·Manica BalantTeresa Garnatje
Nov 21, 2021·Drugs·Mary-Ann FitzcharlesWinfried Häuser

❮ Previous
Next ❯

Software Mentioned

atable
pheatmap
Qualtrics
tidyverse
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cephalalgia : an International Journal of Headache
P T DaviesF Clifford Rose
Aǧrı : Ağrı (Algoloji) Derneği'nin Yayın organıdır = The journal of the Turkish Society of Algology
Arzu Çoban
Vascular Pharmacology
D K ArulmozhiS L Bodhankar
© 2022 Meta ULC. All rights reserved