Migraine in patients with systemic lupus erythematosus is associated with reduced cerebral grey matter volume but not with measures of glial activation or anti-NR2 or anti-P antibodies

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Anne B TjensvollRoald Omdal

Abstract

Migraine is frequent in patients with systemic lupus erythematosus (SLE), but the pathogenesis and pathophysiology are poorly understood. Migraine is assumed to be a consequence of abnormal neuronal excitability. Based on the hypothesis that the threshold for migraine is lower in SLE patients due to cerebral disturbances, whether structural abnormalities of the brain or relevant biomarkers are associated with headaches in SLE was investigated. Sixty-seven SLE patients and age- and gender-matched healthy subjects participated. Volumes of grey matter (GM) and white matter (WM) were estimated from cerebral magnetic resonance images with SPM8 software. Anti-NR2 and anti-P antibodies and protein S100B were measured in cerebrospinal fluid. In regression analyses, larger GM volumes in SLE patients reduced the odds for headache in general [odds ratio (OR) 0.98, P = 0.048] and for migraine in particular (OR 0.95, P = 0.004). No localized loss of GM was observed. Larger WM volumes in patients increased the odds for migraine (OR 1.04, P = 0.007). These findings could not be confirmed in healthy subjects. Neither anti-NR2 and anti-P antibodies nor S100B were associated with headaches in SLE patients. Systemic lupus erythematosus patients w...Continue Reading

References

Jan 1, 1974·Modern Problems of Pharmacopsychiatry·A T Beck, A Beamesderfer
Feb 22, 2003·Hand Surgery : an International Journal Devoted to Hand and Upper Limb Surgery and Related Research : Journal of the Asia-Pacific Federation of Societies for Surgery of the Hand·Y TaniguchiM Yoshida
Nov 30, 2004·Cephalalgia : an International Journal of Headache·S Appenzeller, L T L Costallat
Apr 5, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R OmdalS I Mellgren
Jan 27, 2006·Clinical Rheumatology·Bruno LessaMittermayer Santiago
Jan 11, 2008·Headache·Walter ValfrèLorenzo Pinessi
Oct 25, 2008·Progress in Neurobiology·Doris D Wang, Angélique Bordey
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Thomas W FaustPatricio T Huerta
Oct 27, 2010·Cephalalgia : an International Journal of Headache·Anne B TjensvollRoald Omdal
Mar 2, 2011·Arthritis and Rheumatism·J LuyendijkM A van Buchem
Apr 3, 2012·The Journal of Rheumatology·Patricia C CagnoliTobias Schmidt-Wilcke
May 29, 2012·Trends in Neurosciences·Dania Vecchia, Daniela Pietrobon
Jul 16, 2013·BMC Medical Research Methodology·Morten W FagerlandPetter Laake
Aug 29, 2013·Arthritis and Rheumatism·Maria B LauvsnesRoald Omdal
Nov 26, 2013·NeuroImage. Clinical·Stuart M GrieveLeanne M Williams
Jun 20, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M B LauvsnesR Omdal
Oct 11, 2014·Arthritis & Rheumatology·Marcela Bravo-ZehnderAlfonso González

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Citations

Oct 17, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H V Schapira
Jun 16, 2018·Frontiers in Medicine·Jessica Fernandes VivaldoSimone Appenzeller

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