Migraine in twins raised together and apart

Headache
D K ZieglerR Barter

Abstract

History of headache and migraine diagnosed by structured interview utilizing International Headache Society criteria was obtained in two samples of female twin pairs--154 raised together and 43 raised apart since infancy. Zygosity was determined by standard methods. Probandwise concordance rates were determined. Assuming that liability to migraine has a multifactorial etiology involving a number of genetic and environmental risk factors acting additively, tetrachoric correlations in the four groups of twins (monozygotic raised together, monozygotic raised apart, dizygotic raised together, and dizygotic raised apart) were then calculated. The genetic and environmental influences in the liability to migraine were estimated using biometrical model-fitting methods. Tetrachoric correlations of migraine were consistently higher in monozygotic than in dizygotic twins, for both reared together and reared apart samples, with a heritability estimate of 52%, Model fitting also suggested that approximately 50% of the variance in liability to migraine was attributable to genetic factors with nonshared environmental factors and measurement errors responsible for the remaining variance.

Citations

Apr 25, 2009·Human Genetics·Carla Chia Ming ChenKerrie L Mengersen
May 2, 2003·Current Pain and Headache Reports·Esther KorsMichel Ferrari
Feb 15, 2001·European Journal of Pharmacology·R A OphoffR R Frants
Jul 10, 2003·Lancet Neurology·Anne DucrosMarie-Germaine Bousser
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·G R UhlZ Wang
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·J S Mogil
May 21, 2009·Human Genetics·Boukje de VriesArn M J M van den Maagdenberg
Jul 6, 2014·Best Practice & Research. Clinical Anaesthesiology·Andrea M Trescot
Jun 5, 2002·Current Opinion in Neurology·Paul Winner, Jack Gladstein
Mar 2, 2010·Expert Review of Neurotherapeutics·Anna P AndreouPeter J Goadsby
Apr 9, 2009·The Journal of Headache and Pain·Federica GalliVincenzo Guidetti
Dec 9, 2008·Clinics in Laboratory Medicine·Lynn R Webster
Feb 22, 2008·Medical Hypotheses·Xiao-Ping WangYong-Bo Zhao
May 19, 2007·Lancet Neurology·Maija WessmanRoel A Ophoff
Aug 25, 2006·Headache·Kathy L Gardner
Jul 25, 2012·Clinical Genetics·C S NielsenÓ A Steingrímsdóttir
Feb 18, 2014·Headache·Jennifer HongGilbert J Fanciullo
Mar 20, 2015·Pain·Else A TolnerArn M J M van den Maagdenberg
Sep 22, 2000·Current Review of Pain·R B Fillingim
Sep 22, 2000·Current Review of Pain·T Wolf, G Arnold
May 10, 2017·Headache·Anne Luise Haulund Vollesen, Messoud Ashina
Mar 26, 2016·Cephalalgia : an International Journal of Headache·Daniel I ChasmanTobias Kurth
Jul 1, 2016·Cephalalgia : an International Journal of Headache·Camillo PorcaroGianluca Coppola
Feb 18, 2018·The Journal of Headache and Pain·Håkan AshinaMessoud Ashina
Oct 30, 2004·Annals of Medicine·Maija WessmanAarno Palotie
Mar 3, 2018·Cephalalgia : an International Journal of Headache·William Renthal
May 22, 2007·Acta Odontologica Scandinavica·Marjo-Riitta LiljeströmMatti Sillanpää
Dec 25, 2019·Neurology. Genetics·Lisette J A KogelmanUNKNOWN DBDS Genomic Consortium, The International Headache Genetics Consortium
Sep 24, 2019·Headache·Julie RavnThomas F Hansen
May 21, 2019·Cephalalgia : an International Journal of Headache·Lisette Ja KogelmanJes Olesen
Apr 9, 2017·Molecular Genetics and Genomics : MGG·Cassie L AlburyLyn R Griffiths

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.