Migraine triggered by sucralose--a case report

Headache
Marcelo E Bigal, Abouch V Krymchantowski

Abstract

Sucralose is the active compound of the most commonly sold sweetener in the United States. Different than aspartame, sucralose is not considered to be a migraine trigger. Herein we report a patient with attacks of migraine consistently triggered by sucralose. She also suffers from menstrually related migraine that had been well-controlled for several months since she switched her contraceptive from fixed estrogen to triphasic contraceptive pills. Some attacks triggered by sucralose were preceded by aura, and she had never experienced migraine with aura before. Withdrawal of the compound was associated with complete resolution of the attacks. Single-blind exposure (vs. sugar) triggered the attacks, after an attack-free period.

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Citations

May 21, 2009·The Clinical Journal of Pain·Christina Sun-Edelstein, Alexander Mauskop
Jun 30, 2007·Cephalalgia : an International Journal of Headache·F MaggioniG Zanchin
Jul 27, 2012·Annals of Nutrition & Metabolism·Md Shahidul Islam, Mitesh Indrajit
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Aug 26, 2021·Environmental Science and Pollution Research International·Sumira MalikVinay Kumar

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