Migrating focal seizures during infancy: a case report and pathologic study

Pediatric Neurology
Lorena FasuloRoberto Horacio Caraballo

Abstract

Migrating focal seizures in infancy are an unusual and often overlooked epilepsy syndrome, with onset before age 6 months, in which nearly continuous seizures involve multiple, independent areas of both hemispheres with an arrest of psychomotor development. We describe a patient with migrating focal seizures in infancy whose seizures began at age 45 days. The seizures were refractory to common antiepileptic drugs. At age 6 months, the infant received potassium bromide and became almost seizure-free. The infant developed severe neurologic impairment, with marked axial hypotonia and an absence of visual contact and head control. At age 8 months, the child suddenly died. Pathologic findings included multiple malformations of cortical development, polymicrogyria, and focal cortical dysplasia associated with hippocampal sclerosis.

References

Dec 7, 2000·Journal of Child Neurology·J M WilmshurstP J Grattan-Smith
Jun 8, 2001·Epilepsy Research·E VeneselliR Biancheri
Dec 27, 2005·Pediatric Neurology·Ghassan HmaimessKenou van Rijckevorsel
Jan 31, 2008·Journal of Child Neurology·Roberto Horacio CaraballoBernardo Dalla Bernardina
Sep 23, 2008·Lancet Neurology·Torbjörn TomsonPhilippe Ryvlin
Aug 27, 2010·Epilepsia·François Le GalThomas Schmitt-Mechelke
May 17, 2011·Forensic Science, Medicine, and Pathology·Christopher M Milroy

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Citations

Aug 24, 2013·Pediatric Neurology·Olcay ÜnverÇetin Okuyaz
Jun 19, 2019·Journal of Child Neurology·Anita N DattaMichelle Demos
May 24, 2014·Expert Review of Neurotherapeutics·Athanasios Covanis
Sep 19, 2019·Brain : a Journal of Neurology·Mathieu KuchenbuchRima Nabbout

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