Migration and fractionation of deformable particles in microchannel

The Journal of Chemical Physics
Chia Wei Hsu, Yeng-Long Chen

Abstract

The complexity of the coupling between soft particle deformation and fluid perturbation has limited studies of soft particle hydrodynamics to dilute suspensions. A hybrid Brownian dynamics-lattice Boltzmann method is presented that models nondilute soft spherical deformable particle (DP) suspensions in flow. Dependences on particle size and density are investigated for suspensions with over 100 DP. Multi-DP interactions lead to complex dependence of particle distributions on concentration and flow rate. Flow-induced DP migration toward channel center for DP in narrow channels is found. In wide channels, off-center peaks in the center of mass distribution for DP are found. The migration of DP leads to faster average speed of DP than the flow, which can be exploited for fractionating DPs of different sizes.

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Citations

Jan 8, 2014·Biomicrofluidics·Hsieh ChenAlfredo Alexander-Katz
Jun 28, 2013·The Journal of Chemical Physics·S Reddig, H Stark
Jun 14, 2013·The Journal of Chemical Physics·Yangwei JiangLinxi Zhang
Apr 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Sam H AuMehmet Toner
Aug 9, 2017·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Chih-Tang LiaoYeng-Long Chen
Mar 1, 2019·Scientific Reports·Izabella Bouhid de AguiarKarin Schroën

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