Migration and healing of ligament cells under inflammatory conditions

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
J WitkowskiK L Sung

Abstract

It is well documented that the adult human medial collateral ligament has a functional healing response, whereas the anterior cruciate ligament does not. The differential healing responses of the medial collateral and anterior cruciate ligaments could be due to factors caused by different biological conditions and locations in vivo. In addition, different intrinsic properties of the constituent cells of these ligaments may contribute to their different healing abilities. Ligament healing follows an orderly process of hemorrhage, inflammation, proliferation, and remodeling. At the cellular level, healing involves a cell's detachment from and attachment to the matrix adjacent to the wound area, migration, and proliferation. This study sought to investigate whether, during migration, the responses of the medial collateral and anterior cruciate ligament fibroblasts are intrinsically different under the same inflammatory conditions. Human medial collateral and anterior cruciate ligament fibroblast cells were cultured, and in vitro wounds were simulated by streaking the cells with an inoculating loop, creating a cell-free area. The migration of the cells into this gap, thus filling the cell-free area, was observed. Two sets of experi...Continue Reading

References

Jan 1, 1979·The American Journal of Sports Medicine·H E CabaudJ A Feagin
Nov 1, 1979·The American Journal of Sports Medicine·J A ArnoldW D Harris
Jul 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C N NagineniW H Akeson
May 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M E WiigK E Arfors
Jun 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·S M RossC B Frank
Jan 1, 1987·Ciba Foundation Symposium
Dec 6, 1973·Biochimica Et Biophysica Acta·A J BaileyA Delaunay
Nov 1, 1983·The American Journal of Sports Medicine·C FrankW Akeson
Jan 1, 1983·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C FrankD Dittrich
Mar 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K L SungW H Akeson
Aug 1, 1994·Journal of Biomechanical Engineering·K L SungW H Akeson
Sep 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K L SungW H Akeson

❮ Previous
Next ❯

Citations

Nov 15, 2003·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Dariusz Witoński, Małgorzata Wagrowska-Danilewicz
Feb 9, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Sven StenerJüri Kartus
Dec 10, 1999·Tissue Engineering·V S LinK L Sung
Feb 5, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Yanjun ZhangKl Paul Sung
Jan 25, 2005·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hideaki MurakamiKoichi Nemoto
Feb 24, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yequan WangLi Yang
Nov 7, 2002·The Journal of Veterinary Medical Science·Yoshinao HosakaKazushige Takehana
Aug 6, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Arnulf PascherMartha Meaney Murray
May 2, 2008·The American Journal of Sports Medicine·Jasmine A BeyePaul T Salo
Nov 24, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R S GoomerD Amiel
Nov 24, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L YangK L Sung
Jul 11, 2007·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Mao-Hsiung HuangPei-Hsi Chou
Jan 13, 2000·Proceedings of the Society for Experimental Biology and Medicine·K D HankensonJ J Turek
Mar 17, 2004·Clinical Orthopaedics and Related Research·Inchan YounJ-K Francis Suh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Related Papers

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
L YangK L Sung
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Yequan WangLi Yang
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Zhenyu TangK-L Paul Sung
© 2021 Meta ULC. All rights reserved