PMID: 11898522Mar 20, 2002Paper

Migration and invasion in brain neoplasms

Current Neurology and Neuroscience Reports
A J BolteusG J Pilkington

Abstract

Local invasion of the brain by neoplastic glial cells is a major obstacle to effective treatment of intrinsic brain tumors. Invasion is directly related to histologic malignancy, but occurs to some extent irrespective of tumor grade. Because the brain-to-tumor interface is not well demarcated, total surgical removal is rarely possible; moreover, as invading cells transiently arrest from cell division they are refractory to radiotherapeutic intervention. Invading cells may also be protected from the action of cytotoxic drugs by the presence of an intact blood-brain barrier. The invading cells, having migrated several millimeters or even centimeters from the main focus of the tumor, return to cycle phase under the control of some as yet unknown microenvironmental cue to form a recurrent tumor adjacent to the original site of presentation. Recent cellular and genetic information concerning factors underlying invasion may not only yield suitable targets for adaptation of existing therapies, but may also lead to novel approaches in glioma management.

References

Oct 1, 1992·Neuropathology and Applied Neurobiology·G J Pilkington
Apr 1, 1994·Brain Pathology·G J Pilkington
Feb 1, 1995·Molecular and Chemical Neuropathology·A MerzakG J Pilkington
Feb 15, 1995·Neuroscience Letters·S KoochekpourG J Pilkington
Mar 1, 1994·Journal of Neurosurgery·W Paulus, J C Tonn
Apr 10, 1996·International Journal of Cancer. Journal International Du Cancer·H OkadaM Hagiwara
May 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S L MaidmentG J Pilkington
May 20, 1998·International Journal of Cancer. Journal International Du Cancer·A SehgalG P Murphy
Feb 27, 1999·International Journal of Cancer. Journal International Du Cancer·J C TonnK Roosen
Sep 4, 1999·Neuropathology and Applied Neurobiology·C Hagel, D K Stavrou
Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M ChekenyaG J Pilkington
Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L L DemchikB F Sloane
Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J T RutkaC Ackerley
Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K LamszusE M Rosen
Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·H K RoopraiG J Pilkington
Apr 25, 2000·The Journal of Biological Chemistry·J MaiB F Sloane
Apr 25, 2000·Journal of Neuro-oncology·S KhoshyomnP L Penar

❮ Previous
Next ❯

Citations

Sep 22, 2005·Acta Neuropathologica·Josef Zamecnik
Mar 23, 2006·Journal of Neuro-oncology·Caren V LundBrian P Eliceiri
Apr 10, 2008·Journal of Neuro-oncology·Mariano Sebastian ViapianoRussell Thomas Matthews
Aug 13, 2004·Neuropathology and Applied Neurobiology·J ZámecníkE Syková
Jul 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chong-Feng GaoGeorge F Vande Woude
Mar 1, 2012·PloS One·Zaynah MaherallyGeoffrey J Pilkington
Sep 25, 2007·Journal of Neurosurgery·Yuji FukushimaKazuyuki Itoh
Apr 7, 2007·Journal of Neurosurgery·Lisa M BernasBrian K Rutt
Nov 6, 2009·Molecular Cancer Research : MCR·Bin HuMariano S Viapiano
Nov 30, 2002·Expert Opinion on Investigational Drugs·Osmond J D'Cruz, Fatih M Uckun
Jan 22, 2008·Seminars in Cancer Biology·Geoffrey J PilkingtonSamantha A Murray
Jul 12, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tove Lind-LandströmSverre H Torp
Oct 31, 2012·Cell Proliferation·L K Donovan, G J Pilkington
Jan 13, 2006·Journal of Neuroscience Methods·N Shastry AkellaL Burton Nabors
Jan 5, 2018·International Journal of Molecular Sciences·Ivana ManiniDaniela Cesselli
Sep 20, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Marie E BecknerIan F Pollack
Nov 23, 2005·Cell Proliferation·G J Pilkington
Feb 26, 2003·The Journal of Biological Chemistry·Patricia A RitchHarald Sontheimer
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Diana M LeiteGeoffrey J Pilkington
Jan 7, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Eunmi HwangSung-Jo Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.