Migration and phenotypic transformation of osteoclast precursors into mature osteoclasts: the effect of a bisphosphonate

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
C LöwikO L Bijvoet

Abstract

Osteoclast-devoid bone explants were cultured together with embryonic liver as a source of osteoclast precursors, but separated from each other by a filter. Cells migrated through the filter toward the calcified matrix and acquired the characteristics of mature, tartrate-resistant acid phosphatase-positive (TRAP+) osteoclasts upon contact with the bone explant. Migration and attachment could be visualized separately. Progressive reduction of filter pore size resulted in progressive reduction of resorption because the use of smaller pores made it increasingly difficult for cells to pass. Indeed, the use of 0.22-micron filters, through which no cells can pass, but which still allow full passage of medium, completely blocked the resorption. When migrating cells from fetal liver were arrested for 10 days by using a combination of filters with different pore sizes, the arrested cells showed a tendency to fuse just opposite the mineralized matrix. Furthermore, a great number of the arrested cells expressed the macrophage-specific cell-surface antigen F4/80 and showed acid phosphatase activity, but none of these cells were tartrate resistant. The acquisition of tartrate-resistant acid phosphatase activity upon contact with the bone ex...Continue Reading

References

Sep 1, 1975·The Anatomical Record·B K Hall
May 1, 1985·The Journal of Cell Biology·M J OurslerP Osdoby
Apr 1, 1986·Calcified Tissue International·P H Stevenson, J R Stevenson
May 1, 1986·Calcified Tissue International·M J MarshallP M Green
Feb 1, 1986·Endocrinology·P M McSheehy, T J Chambers
Aug 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J GlowackiS Goldring
Oct 1, 1986·Physiological Reviews·P J NijweideJ H Feyen
Oct 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·F P van de Wijngaert, E H Burger
May 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P H NibberingR Van Furth
Dec 1, 1984·The Journal of Cell Biology·E H BurgerP J Nijweide
Sep 1, 1982·Calcified Tissue International·M Krukowski, A J Kahn
Dec 1, 1982·The Journal of Experimental Medicine·E H BurgerR van Furth
Oct 1, 1981·European Journal of Immunology·J M Austyn, S Gordon

❮ Previous
Next ❯

Citations

Sep 1, 1996·Obstetrics and Gynecology·S GianniniG Crepaldi
Mar 26, 2004·European Urology·Jean-Claude DumonJean-Jacques Body
May 1, 1994·Bone and Mineral·H DenissenA van den Hooff
Jan 1, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Olga L HukAlain Petit
Mar 22, 2002·The International Journal of Biochemistry & Cell Biology·C E Evans
Feb 1, 1990·The Journal of Clinical Investigation·A CaranoH C Blair
Dec 1, 1991·The Journal of Clinical Investigation·M SatoG A Rodan
Nov 1, 1995·The Journal of Clinical Investigation·Z ZimoloG A Rodan
Aug 1, 1996·The Journal of Clinical Investigation·G van der PluijmS Papapoulos
Nov 9, 2005·Journal of Periodontology·Adriana M A MenezesGerly Anne C Brito
Aug 10, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Keiko SuzukiHisashi Shinoda
Jul 16, 2014·BMC Clinical Pathology·Fabrice Mac-WayMarie-Hélène Lafage-Proust
Aug 3, 2016·Therapeutic Advances in Medical Oncology·Knut Liepe, Ajit Shinto
Jan 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H Fleisch
Apr 28, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anke J RoelofsMichael J Rogers
Aug 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G van der PluijmS Papapoulos
Nov 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G van der PluijmS E Papapoulos
Oct 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M J RogersR G Russell
Apr 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J G SeedorD D Thompson
Aug 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·V Paspaliaris, D D Leaver
Feb 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R W BoyceE F Eriksen
Oct 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S E PapapoulosO L Bijvoet
Jul 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M J RogersF H Ebetino
Jan 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H KodamaH Kawashima
Feb 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·I P Braidman, D C Anderson
Dec 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E van BeekS Papapoulos
Jan 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R D DevlinG K Worth
Oct 12, 2018·EFORT Open Reviews·Morten Schultz Larsen, Hagen Schmal
May 21, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L J KiddM R Forwood
Jan 1, 1993·Calcified Tissue International·M J MarshallM W Davie
Nov 15, 1997·Cancer·M J RogersR G Russell
Nov 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S P LuckmanM J Rogers
Oct 6, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R G RussellH A Fleisch
Feb 26, 2003·Journal of Biomedical Materials Research. Part a·Jui-Sheng SunLi-Ting Chen
Jan 10, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anke J RoelofsFraser P Coxon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
M G CecchiniP H Cooper
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
S E PapapoulosO L Bijvoet
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
M G Cecchini, H Fleisch
© 2021 Meta ULC. All rights reserved