journal cover

Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness

Biophysical Journal

Sep 4, 2015

Lena A LautschamBen Fabry

Abstract

In cancer metastasis and other physiological processes, cells migrate through the three-dimensional (3D) extracellular matrix of connective tissue and must overcome the steric hindrance posed by pores that are smaller than the cells. It is currently assumed that low cell stiffness promo...read more

Mentioned in this Paper

Three-dimensional
Cell Motility
poly(dimethylsiloxane)-polyamide copolymer
Extracellular Matrix
Muscular Stiffness
LMNA
Cell Nucleus
SUN2
Anatomical Space Structure
Cell Nucleus Volume
2
180
1
Paper Details
References
  • References50
  • Citations28
12345
  • References50
  • Citations28
123

Similar Papers Found In These Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Multiple Cell Adhesion Molecules

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cytoplasmic Biophysics

Cytoplasmic biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study the biological structure and function of cytoplasm which consists of cytosol and organelles. Discover the latest research on cytoplasmic biophysics here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Embryonic Blastomere Cell Adhesion

Viral Packing & Assembly

Viral capsids typically self-assemble around the viral genome in the host cytoplasm. This feed focuses on mechanisms that play a role in packaging viral DNA into the capsid.

© 2020 Meta ULC. All rights reserved

Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness

Biophysical Journal

Sep 4, 2015

Lena A LautschamBen Fabry

PMID: 26331248

DOI: 10.1016/j.bpj.2015.07.025

Abstract

In cancer metastasis and other physiological processes, cells migrate through the three-dimensional (3D) extracellular matrix of connective tissue and must overcome the steric hindrance posed by pores that are smaller than the cells. It is currently assumed that low cell stiffness promo...read more

Mentioned in this Paper

Three-dimensional
Cell Motility
poly(dimethylsiloxane)-polyamide copolymer
Extracellular Matrix
Muscular Stiffness
LMNA
Cell Nucleus
SUN2
Anatomical Space Structure
Cell Nucleus Volume
2
180
1

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References50
  • Citations28
12345
  • References50
  • Citations28
123
/papers/migration-in-confined-3d-environments-is/26331248