Migration of B lymphocytes in lymphoid organs of lethally irradiated, thymocyte-reconstituted mice

Cell and Tissue Research
W van Ewijk, T H van der Kwast

Abstract

The migration of radiolabeled intravenously injected B lymphocytes through thymus-dependent areas was studied in lymphoid organs of mice with experimentally defined T cell domains (B cell-deprived mice or "T" mice). In the spleen, B cells were found to enter the peri-arteriolar lymphoid sheath (PALS) by two routes: (i) via the marginal zone, and (ii) via reticulum sheaths surrounding terminal arterioles. B cells migrated through the peripheral and central PALS and initiated the formation of primary follicles in the peripheral PALS 6 h after injection. Distinct primary follicles were noted at 18 h after injection of the labelled B cells. After 24 h small numbers of labelled cells were also noted in the efferent lymphatic vessels of the spleen. The reconstitution of B cell compartments in the mesenteric lymph node was delayed compared to the spleen. B cells entered the nodal stroma across the wall of high endothelial venules in the paracortex and by 6 h were found scattered throughout the paracortex. Isolated clusters of a few labeled cells were noted in the outer cortex at 18 h after cell transfer. Defined primary nodules were seen only 24 h after reconstitution. A minority of labeled cells was found at 24 h in the cortico-medul...Continue Reading

Citations

Jan 1, 1984·Cell and Tissue Research·R BrelińskaI Reisert
Mar 13, 2008·International Immunology·Tilo Beyer, Michael Meyer-Hermann
Oct 6, 2007·Science·Kamal M KhannaLeo Lefrançois
Apr 2, 2015·Immunology·Birte S Steiniger
Oct 13, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Tilo Beyer, Michael Meyer-Hermann

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