PMID: 7544698May 26, 1995Paper

Migration of dopaminergic neurons in the embryonic mesencephalon of mice

Brain Research. Developmental Brain Research
H KawanoI Nagatsu

Abstract

Migration of dopamine (DA)-containing neurons and its guiding cues were histologically examined in the embryonic mesencephalon of normal mice. Cells immunoreactive (ir) for tyrosine hydroxylase (TH), a DA-synthesizing enzyme, were first detected on embryonic day 10 (E10) in the medio-basal part of the mesencephalon and were distributed throughout the entire length of the ventral mesencephalic wall at E12. By E14, TH-ir cells were located laterally along the ventral pial surface to form the primordia of the substantia nigra. Experiments with a single injection of bromodeoxyuridine, a thymidine analog, demonstrated that cells generated in the ventricular surface of the ventral mesencephalon at E11 migrated ventrally and then moved laterally to form the substantia nigra and the ventral tegmental area. Electron microscopic examination of the ventral mesencephalon of E12 mice disclosed that in the dorsal part ventrally migrating immature neurons made close contacts with the processes of radial glial cells. The expression of tenascin was transiently seen on radial glial processes between E10 and E13 coincident with the period of the ventral migration of mesencephalic DA neurons. By double immunostaining of E13 mesencephalon, ventrall...Continue Reading

References

Jul 1, 1992·Neuron·A L Halliday, C L Cepko
Aug 1, 1990·Brain Research. Developmental Brain Research·J P GriersonH M Geller
Jan 1, 1991·Anatomy and Embryology·S YuasaY Takahashi
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·U Di PorzioJ L Barker
Sep 15, 1990·Experientia·P Rakic
Jan 1, 1990·Anatomy and Embryology·K Ono, K Kawamura
Oct 1, 1988·Journal of Neuroscience Research·M Bronner-Fraser
Sep 1, 1989·Trends in Neurosciences·M G Honig, R I Hume
May 1, 1972·The Journal of Comparative Neurology·P Rakic
Jan 1, 1972·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·L Olson, A Seiger
Oct 1, 1973·Experimental Neurology·M Shimada, T Nakamura
Aug 1, 1973·Developmental Biology·G S Golden
Jan 1, 1984·The Journal of Cell Biology·M E HattenC A Mason
Jun 1, 1983·Neuroscience·R Marchand, L J Poirier
Feb 1, 1993·Current Opinion in Neurobiology·M E Hatten

❮ Previous
Next ❯

Citations

Nov 14, 2000·The Journal of Comparative Neurology·C FrassoniR Spreafico
Nov 23, 2010·Psychopharmacology·Ana-João RodriguesNuno Sousa
Aug 10, 2004·Cell and Tissue Research·Marten P SmidtJ Peter H Burbach
Jun 14, 1996·Brain Research. Developmental Brain Research·K LiebC Pilgrim
Sep 8, 2005·Brain Research Bulletin·Ana DelgadoCarmen M Trujillo
Jun 25, 2003·Experimental Neurology·Hitoshi KawanoShioko Kimura
Sep 30, 2000·Brain Research. Brain Research Reviews·W J Smeets, A González
Feb 15, 2001·Brain Research. Developmental Brain Research·G P DemyanenkoP F Maness
Mar 23, 2000·Brain Research. Developmental Brain Research·T FukudaK Kawamura
May 15, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Doreen Siu Yi LeungBernhard Reuss
Mar 14, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·A Joester, A Faissner
Sep 10, 2002·Parkinsonism & Related Disorders·Hideyuki OkanoKazunobu Sawamoto
Dec 21, 2006·Nature Reviews. Neuroscience·Marten P Smidt, J Peter H Burbach
Dec 14, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Simon McArthurGlenda E Gillies
Jan 22, 2003·The European Journal of Neuroscience·Masao HorieHitoshi Kawano
Jul 19, 2002·Journal of Neurochemistry·Natsuki MatsushitaKazuto Kobayashi
Dec 11, 2002·Journal of Neurochemistry·Yongquan LuoMahendra Rao
Aug 16, 2006·Neuro-degenerative Diseases·Gonçalo Castelo-Branco, Ernest Arenas
Dec 28, 2007·Cells, Tissues, Organs·Alexander von Holst
Nov 11, 2011·BMC Developmental Biology·Minoru KawakamiKen-Ichi Yamamura
May 17, 2011·Neural Development·Maria T M Alves dos Santos, Marten P Smidt
Aug 9, 2012·Development·Anju VasudevanKwang-Soo Kim
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·K SawamotoH Okano
Jan 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi KawasakiYoshiki Sasai
Nov 19, 2015·Stem Cells and Development·Lisa WagenführAlexander Storch
Nov 10, 2015·Genes, Brain, and Behavior·G B Bissonette, M R Roesch
Mar 10, 2015·ACS Chemical Neuroscience·Vera NiederkoflerSusan M Dymecki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.