PMID: 9186623Apr 15, 1997Paper

Migration of medial smooth muscle cells to the intima after balloon injury

Annals of the New York Academy of Sciences
Y YoshidaQ Shu

Abstract

Migration to the intima and other responses of M-SMC in the rat carotid artery and abdominal aorta after balloon injury were investigated in vivo. Migration occurred intensively between the second and fifth days after injury. About 80% of the cells were in the G1 and S phases of the cell cycle. The majority of the migrating cells were therefore simultaneously proliferating. Positive values of 42.3%, 48.9%, 44.4%, and 32.8% of the migrating cells on the fifth day in the carotid artery for PDGF-B, elastase III B, MMP-I, and MMP-9, were observed, respectively. Many of the cells expressed messages of PDGF-A and elastases II and III B by in situ hybridization. Fine structures of the migrating cells were characterized as a synthetic phenotype of the smooth muscle cell with reduced attachment to their surrounding ECM. A biphasic proliferative response of the M-SMC appeared on the second and fifth days. Migration occurred correspondingly in the proliferative period. The populations of M-SMC positive in immunostainings for PDGFs, their receptors, elastase III B, and MMP-1 and MMP-9 also increased biphasically, around 12 h and five days after the injury. The results of these studies suggest that the migrating cells were proliferative and...Continue Reading

Citations

May 29, 2002·Tissue Engineering·Arthur H WongMichael D Dake
Apr 23, 2010·Journal of Cardiovascular Pharmacology·Andriy O SamokhinDieter Brömme
Dec 21, 2005·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Philippe G AmabileMichael D Dake
Jun 19, 2013·The Journal of Surgical Research·Deidra J H MountainOscar H Grandas
Jul 23, 2011·The Journal of Surgical Research·Deidra J H MountainOscar H Grandas
Sep 4, 2009·The Journal of Surgical Research·A Mike TummersOscar H Grandas
Sep 1, 2007·Journal of the American Society of Hypertension : JASH·Edward G Lakatta
Dec 6, 2000·The Journal of Surgical Research·G JinS Chien
Aug 11, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·A W BaroletB H Strauss
Sep 4, 2015·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Joo-Hui HanChang-Seon Myung
Dec 4, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Daming ZhuangAviv Hassid
Dec 26, 2018·Expert Review of Cardiovascular Therapy·Mohan Satish, Devendra K Agrawal
Jun 17, 2020·Expert Review of Medical Devices·Juan J Rodríguez-AriasSalvatore Brugaletta
Aug 2, 2020·Molecular and Cellular Biochemistry·Mohan SatishDevendra K Agrawal
Mar 28, 2013·British Medical Bulletin·Javaid IqbalPatrick W Serruys
Apr 13, 2000·International Journal of Experimental Pathology·G A Ferns, T Y Avades
Dec 10, 2020·The New England Journal of Medicine·Joakim NordanstigMårten Falkenberg
Feb 16, 2021·Progress in Cardiovascular Diseases·Vishal AmlaniJoakim Nordanstig

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