Migration of smooth muscle cells from the arterial anastomosis of arteriovenous fistulas requires Notch activation to form neointima

Kidney International
Ming LiangJizhong Cheng

Abstract

A major factor contributing to failure of arteriovenous fistulas (AVFs) is migration of smooth muscle cells into the forming neointima. To identify the source of smooth muscle cells in neointima, we created end-to-end AVFs by anastomosing the common carotid artery to the jugular vein and studied neural crest-derived smooth muscle cells from the carotid artery, which are Wnt1-positive during development. In Wnt1-cre-GFP mice, smooth muscle cells in the carotid artery but not the jugular vein are labeled with GFP. About half of the cells were GFP-positive in the neointima, indicating their migration from the carotid artery to the jugular vein in AVFs created in these mice. As fibroblast-specific protein-1 (FSP-1) regulates smooth muscle cell migration, we examined FSP-1 in failed AVFs and polytetrafluoroethylene grafts from patients with end-stage kidney disease or from AVFs in mice with chronic kidney disease. In smooth muscle cells of AVFs or polytetrafluoroethylene grafts, FSP-1 and activation of Notch1 are present. In smooth muscle cells, Notch1 increased RBP-Jκ transcription factor activity and RBP-Jκ stimulated FSP-1 expression. Conditional knockout of RBP-Jκ in smooth muscle cells or general knockout of FSP-1 suppressed ne...Continue Reading

References

Mar 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K L WaldoM L Kirby
Sep 18, 2002·Kidney International·Michael Allon, Michelle L Robbin
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Wei-Jun CaiJutta Schaper
Sep 4, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Yasuhiko SakataMichael T Chin
Jan 24, 2006·Nature Cell Biology·Mikko NieminenSirpa Jalkanen
Mar 28, 2006·Journal of the American Society of Nephrology : JASN·Prabir Roy-ChaudhuryAlfred K Cheung
Sep 30, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Jacob F BentzonErling Falk
Nov 18, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Mark H HoofnagleGary K Owens
Jan 17, 2007·Seminars in Cell & Developmental Biology·Mary R Hutson, Margaret L Kirby
Mar 9, 2007·American Journal of Physiology. Renal Physiology·Noel M CapliceKarl A Nath
Mar 27, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Enrique ArciniegasKurt R Stenmark
May 22, 2007·Experimental Cell Research·Johanna IvaskaJohn E Eriksson
Sep 13, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kimie TanakaRyozo Nagai
Oct 24, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Prabir Roy-ChaudhuryRino Munda
Apr 21, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Prabir Roy-ChaudhuryLois Arend
May 9, 2009·Journal of the American Society of Nephrology : JASN·Taku KokuboEric T Choi
Jan 9, 2010·Journal of the American Society of Nephrology : JASN·Liping ZhangWilliam E Mitch
Jun 26, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Jan-Marcus DanielDaniel G Sedding
Jan 15, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Mette K HagensenJacob F Bentzon
Feb 2, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Liping ZhangWilliam E Mitch
Feb 4, 2011·American Journal of Physiology. Cell Physiology·Min ChenKathleen L O'Connor
Feb 19, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Vincenza CaoloMark J Post
Mar 12, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Laura M Dember
Mar 25, 2011·American Journal of Physiology. Renal Physiology·Michael S ForbesRobert L Chevalier
Apr 27, 2011·Seminars in Dialysis·Nikolaos SkartsisRoberto I Vazquez-Padron
Nov 26, 2011·Circulation Research·Jizhong ChengJie Du
Apr 12, 2013·American Journal of Physiology. Renal Physiology·Anlin LiangJizhong Cheng
May 21, 2013·Journal of Vascular Surgery·Chun-Yu WongJoris I Rotmans
Jan 7, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Jui M Dave, Kayla J Bayless
Feb 1, 2014·Journal of the American Society of Nephrology : JASN·Laura M Dember, Katalin Susztak
Feb 1, 2014·Journal of the American Society of Nephrology : JASN·Yun WangJizhong Cheng

❮ Previous
Next ❯

Citations

Nov 26, 2015·Annals of Vascular Surgery·David HasenstabTed R Kohler
Dec 10, 2015·The International Journal of Biochemistry & Cell Biology·Haifeng LiuHongjian Li
Jul 3, 2016·Physiological Reports·Ana C de BragançaDavid P Basile
Sep 19, 2018·PLoS Biology·Shizheng HuangKatalin Susztak
Jul 23, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Jinjing ZhaoXiaochun Long
Apr 1, 2017·Journal of the American Heart Association·Jinjing ZhaoXiaochun Long
Nov 12, 2017·Journal of the American Society of Nephrology : JASN·Jinlong LuoJizhong Cheng
Nov 2, 2019·International Journal of Molecular Sciences·Nirvana SadaghianlooNathalie M Mazure
Jun 9, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Taisiya BezhaevaJoris I Rotmans
May 12, 2020·Vascular·Hualong BaiAlan Dardik
Aug 2, 2017·International Journal of Molecular Sciences·Ding-Yuan TianYun Wang
Nov 3, 2017·JCI Insight·Sara N KoenigVidu Garg
May 8, 2021·The Journal of Vascular Access·Roberto I Vazquez-PadronMarwan Tabbara
Jul 16, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Carlos J Martos-RodríguezJacob F Bentzon
Oct 5, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·An-Ni SongChun Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
ChIP
PCR
Assay
Immunoprecipitation Assay
immunoprecipitation
electrophoresis

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.