PMID: 2876737Oct 1, 1986

Migration of T-lymphocyte precursors into the thymus and the factors affecting this process

Biulleten' eksperimental'noĭ biologii i meditsiny
A A IarilinA V Filatov


Migration of FITC-labeled mouse bone marrow cells into the thymus was measured by flow cytometric analysis 3 hours after intravenous injection of cells into irradiated mice. The percentage of cells reaching the thymus diminished when the dose of injected cells increased. The dependence of the number or labeled cells in the thymus on the dose of injected cells was not linear. Pretreatment of cells with anti-SC-I serum, peanut lectin or H-2 incompatibility antigen abolished thymus migration, while treatment with anti-Thy-I serum, soybean lectin, trypsin or Thy-I-incompatibility antigen diminished cellular migration and treatment with neuraminidase enhanced it. It was concluded that the main type of migrating cells is SC-1+ precursors of T-lymphocytes. Penetration of these cells through the blood-thymus barrier is based on the recognition of their partly sialized surface glycoprotein receptors by membrane lectins of the blood-thymus barrier cells.


Nov 1, 1991·Neuroscience and Behavioral Physiology·E V Ignat'evaL N Ivanova
Apr 22, 2015·Bulletin of Experimental Biology and Medicine·A V NovoseletskayaV I Sergienko


Aug 1, 1972·The Journal of Experimental Medicine·E S Golub
Sep 10, 1981·Nature·F Lepault, I L Weissman
May 1, 1982·European Journal of Immunology·R S Basch, J W Berman
Mar 1, 1983·The Journal of Cell Biology·L M Stoolman, S D Rosen
Jan 1, 1980·Journal of Immunological Methods·E C Butcher, I L Weissman

Related Concepts

Cell Motility
Neoplasm of Uncertain or Unknown Behavior of Thymus
Intravenous Injections
Disease of Thymus Gland
Thymic Tissue

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