Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response

Experimental Cell Research
G BoguslawskiDenis English

Abstract

The bioactive lipids sphingosine 1-phosphate (SPP), sphingosylphosphorylcholine, and lysophosphatidic acid play an important role in angiogenesis as a result of their effects on both the migration of endothelial cells (ECs) and the integrity of EC monolayers. Here we show that extremely low concentrations of serum and nanomolar concentrations of these biologically active lipids stimulate migration of human aortic smooth muscle cells (SMCs). However, at dosages most effective in promoting EC migration and in enhancing EC monolayer integrity, serum and SPP potently inhibited SMC migration; SPP also blocked the migration induced by protein growth factors. Treatment of SMCs with SPP induced transient phosphorylation of a 175- to 185-kDa protein corresponding to the PDGF receptor, indicating transactivation of this receptor. SPP and related lipids may play a key role in angiogenesis by coordinating the migration of both endothelial cells and vascular smooth muscle cells in response to the changing gradients of these bioactive lipid messengers.

Citations

Apr 3, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Keith D BarlowLinda J Metheny-Barlow
Apr 25, 2006·The Journal of Pharmacology and Experimental Therapeutics·Kevin J FrenchCharles D Smith
Oct 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Hsin-Yuan ChengSusan S Smyth
Oct 30, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Manikandan PanchatcharamSusan S Smyth
Mar 28, 2008·American Journal of Respiratory Cell and Molecular Biology·Mitsu HashimotoStephen I Rennard
Dec 14, 2011·Clinical Lipidology·Mei-Zhen Cui
Mar 16, 2007·Experimental Dermatology·Yoo Bin KwonJeung-Hoon Lee
Nov 29, 2007·Progress in Lipid Research·Graeme F NixonIrene Hunter
Jul 20, 2004·Journal of Cellular Biochemistry·Julie D Saba
Jul 13, 2004·The Journal of Biological Chemistry·Bettina SauerBurkhard Kleuser
Oct 29, 2002·FEBS Letters·Shawn G PayneSarah Spiegel
Mar 17, 2007·Circulation Research·William T Gerthoffer
Dec 15, 2006·Journal of Cellular Physiology·Kevin A HarveyRafat A Siddiqui
Jun 19, 2007·Biochemistry. Biokhimii︠a︡·E V Dyatlovitskaya
Apr 20, 2010·Molecular and Cellular Biochemistry·Kevin A HarveyRafat A Siddiqui
Aug 11, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Sheng LiKazuhiro Kohama
Feb 24, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Hong Hui WangKazuhiro Kohama
Aug 31, 2011·Stem Cells International·Alexander KlegerThomas Seufferlein
Aug 6, 2013·Cellular and Molecular Life Sciences : CMLS·Kristina Y Aguilera, Rolf A Brekken
Apr 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kwan-Sik KimYan Xu
May 27, 2020·Essays in Biochemistry·Denise G Hemmings, David N Brindley
Oct 27, 2004·British Journal of Pharmacology·Astrid E AlewijnseMartin C Michel
Feb 12, 2011·British Journal of Pharmacology·Mirjam SchuchardtMarkus van der Giet
Jul 24, 2004·Seminars in Cell & Developmental Biology·Saubhik SenguptaYan Xu
Aug 8, 2006·Biochimica Et Biophysica Acta·Chiara Donati, Paola Bruni
Nov 2, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ying ZhangSei Kobayashi

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