Migratory responses of murine hepatic myeloid, lymphoid-related, and plasmacytoid dendritic cells to CC chemokines

Transplantation
Masanore AbeAngus W Thomson

Abstract

Dendritic cell (DC) trafficking is regulated by chemokine receptor expression and responsiveness to chemokines. The authors compared CC chemokine receptor (CCR) expression by mouse liver myeloid, "lymphoid-related," and plasmacytoid DC subsets and their responsiveness to CC chemokines. CCR mRNA expression by liver DC subsets was evaluated by RNase protection assay. In vitro migration of the DC in response to recombinant murine CC chemokines was assayed using Transwell chambers. Immature liver DC did not respond to any CC chemokines tested, despite expression of mRNA encoding appropriate receptors for their ligands. CCR7 expression by each liver DC subset was strongly enhanced in response to maturation. The migratory capacity of liver plasmacytoid DC was similar to that of liver myeloid and lymphoid-related DC. These findings suggest that targeting of CCR7 and its ligands may be a potential approach for manipulation of liver DC trafficking to secondary lymphoid tissue after liver transplantation.

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Citations

Feb 25, 2006·Nature Reviews. Immunology·David H Adams, Bertus Eksteen
Oct 26, 2010·Nature Reviews. Immunology·Angus W Thomson, Percy A Knolle
Nov 26, 2008·Clinics in Laboratory Medicine·Bridget L ColvinAngus W Thomson
Nov 22, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tina L SumpterAngus W Thomson
Aug 19, 2006·European Journal of Immunology·Masanori AbeAngus W Thomson
Jul 8, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sherry A WuenschIan N Crispe
Jun 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alexander I AspinallDavid H Adams
Jan 3, 2006·Transplantation Proceedings·M AbeA W Thomson
Dec 7, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Masanori Abe, Angus W Thomson
Jul 14, 2010·Trends in Immunology·M KernP A Knolle
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Florentina PascaleIsabelle Schwartz-Cornil
Aug 8, 2020·Nature Reviews. Gastroenterology & Hepatology·Angus W ThomsonAlberto Sanchez-Fueyo
Jun 26, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mirjam KoolHamida Hammad
Oct 22, 2019·Frontiers in Cell and Developmental Biology·Yan YanQinxue Hu

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