Abstract
The migration and invasion inhibitory protein (MIIP) was shown to function as a tumor suppressor gene in gliomas by inhibiting tumor cell growth, migration, and invasion. However, its role and clinical significance in esophageal squamous cell carcinoma (ESCC) have not been elucidated. We investigated the correlation of MIIP expression and clinical outcome in a group of surgically resected ESCCs. Tissue microarrays constructed of 253 surgically resected ESCC primary tumors and paired paracancerous normal esophageal epithelia were used for MIIP evaluation by immunohistochemistry. The clinical and prognostic significance of MIIP expression was analyzed statistically. The expression of MIIP expression in cancer tissues was increased significantly in comparison with the paired paracancerous normal epithelia (P < 0.001). And, MIIP expression was associated with ESCC cells' differentiation (P < 0.001). By Kaplan-Meier analysis, patients with low MIIP expression exhibited significantly improved overall survival (OS, P = 0.039) and a tendency of improved disease-free survival (DFS, P = 0.086) than those with high MIIP expression. In addition, MIIP expression could distinguish OS or DFS of patients with tumors in stage T3-4 (P = 0.020, 0...Continue Reading
References
Jul 14, 1998·Nature Medicine·J KononenO P Kallioniemi
Nov 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sonya W SongWei Zhang
Jul 9, 2009·Cancer Research·Nan HuMaxwell P Lee
Dec 17, 2009·The Journal of Biological Chemistry·Ying WuWei Zhang
Apr 27, 2010·Oncogene·P JiW Zhang
Dec 31, 2010·Current Protein & Peptide Science·Yingmei WangWei Zhang
Jun 21, 2011·The Lancet Oncology·Katrin M SjoquistUNKNOWN Australasian Gastro-Intestinal Trials Group
Oct 18, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A HerskovicM Al-Sarraf
Jun 1, 2012·The New England Journal of Medicine·P van HagenUNKNOWN CROSS Group
Feb 23, 2013·Annals of Surgical Oncology·Jing WenJian-Hua Fu
Aug 15, 2013·British Journal of Cancer·H X YangJ H Fu
Sep 7, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhi-Zhou ShiMing-Rong Wang
Jul 2, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christophe MarietteJean-François Seitz
Nov 2, 2014·Oncology Letters·Xinhua WangYuzhi An
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Apr 16, 2015·Oncology Reports·Fangfang SongKexin Chen
May 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A HerskovicM Al-Sarraf