mIL-2R, T cell subsets & hepatitis C

World Journal of Gastroenterology : WJG
Chao-pin LiBo-Rong Pan

Abstract

To study the levels of membrane interleukin-2 receptor (mIL-2R) and T cell subsets in peripheral blood mononuclear cells (PBMC) from patients with hepatitis C and their role in the pathogenesis of hepatitis C. The levels of mIL-2R and T cells subsets in PBMC were detected by biotin- streptatividin (BSA) technique before and after stimulation with PHA in 203 patients with hepatitis C with HCV-RNA(+), anti-HCV(+), anti-HCV(-). The total expressive levels of mIL-2R before and after stimulation with PHA(0.03+/-0.01, 0.03+/-0.02, 0.04+/-0.02, 0.36+/-0.03), and T cell subsets in PBMC (0.62+/-0.06, 0.37+/-0.05, 0.35+/-0.07) were all lower in patients with hepatitis C than those in normal controls (0.66+/-0.07, 0.41+/-0.06, 0.31+/-0.05, P<0.01). Among the patients, the levels of mIL-2R were lower in silence than those in situation of PHA inducting (P<0.01). However, the levels of mIL-2R were similar in acute hepatitis C to that in chronic hepatitis C (P>0.05). The levels of CD(3)(+), CD(4)(+), CD(4)(+)/CD(8)(+) were lower and CD(8)(+) was higher in patients with acute and chronic hepatitis C with anti-HCV(+) than those in normal controls (0.62+/-0.06, 0.37+/-0.05, 0.35+/-0.07, 1.18+/-0.30, 0.61+/-0.07, 0.37+/-0.05, 1.39+/-0.33, 0.31+/-...Continue Reading

References

Jan 31, 2002·World Journal of Gastroenterology : WJG·Li-Fa ZhangYong-Huang Tang
Jan 31, 2002·World Journal of Gastroenterology : WJG·Yu-Hui LiuJing-An Rui
Jan 31, 2002·World Journal of Gastroenterology : WJG·Fen-Lu ZhuZhong-Tian Qi
Jan 31, 2002·World Journal of Gastroenterology : WJG·Jian-Min YangYuan-Hui Luo

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Citations

Oct 16, 2002·World Journal of Gastroenterology : WJG·Jie YanXiao-Zhi Zhong
Mar 25, 2004·World Journal of Gastroenterology : WJG·Hua-Zhang GuoHai-Tao Wang

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