Mild and selective reduction of aldehydes utilising sodium dithionite under flow conditions

Beilstein Journal of Organic Chemistry
Nicole C Neyt, Darren L Riley

Abstract

We recently reported a novel hybrid batch-flow synthesis of the antipsychotic drug clozapine in which the reduction of a nitroaryl group is described under flow conditions using sodium dithionite. We now report the expansion of this method to include the reduction of aldehydes. The method developed affords yields which are comparable to those under batch conditions, has a reduced reaction time and improved space-time productivity. Furthermore, the approach allows the selective reduction of aldehydes in the presence of ketones and has been demonstrated as a continuous process.

References

Sep 15, 2011·Beilstein Journal of Organic Chemistry·Andreas Kirschning
Apr 15, 2014·Angewandte Chemie·Sean NewtonSteven V Ley
Jan 15, 2015·Angewandte Chemie·Steven V LeyRebecca M Myers
Jun 2, 2017·Chemical Reviews·Matthew B PlutschackPeter H Seeberger

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