Mild androgen insensitivity presenting with sexual dysfunction

Fertility and Sterility
T F CundyM J Wheeler

Abstract

A man presented with sexual dysfunction and was found to have elevated serum levels of both gonadotropins and T, suggesting AIS. Small external genitalia were the only phenotypic abnormality. Serum T levels increased appropriately in response to hCG and CC, but the patient was severely oligospermic, and testicular biopsy study revealed profoundly impaired spermatogenesis. Studied on androgen receptors in genital skin fibroblasts were normal. PAIS with a virtually normal male phenotype can present in adulthood with sexual dysfunction as well as infertility. As with the syndrome of complete AIS, androgen receptor studies indicate that this is a heterogeneous group of disorders.

Citations

Aug 12, 2014·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Manuel NistalMiguel Reyes-Múgica
Jan 1, 1989·American Journal of Medical Genetics·L PinskyD W Killinger
Mar 23, 2000·American Journal of Medical Genetics·B GottliebM Trifiro
Mar 28, 2013·Case Reports in Obstetrics and Gynecology·Alfonsa PizzoNella Dugo
Jul 1, 1995·Baillière's Clinical Endocrinology and Metabolism·J D Zajac, G L Warne

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