Mild chronic watery diarrhea-hypokalemia syndrome associated with pancreatic islet cell hyperplasia. Elevated plasma and tissue levels of gastric inhibitory polypeptide and successful management with nicotinic acid

The American Journal of Medicine
G S KiddF Newman

Abstract

A 46 year old woman is described who had a 13 half year history of watery diarrhea associated with hypokalemia and hypochlorhydria. The diarrhea was secretory as measured by triple lumen tube perfusion and was associated with an increased concentration of fasting plasma immunoreactive gastric inhibitory polypeptide (GIP) of 750 pg/ml which was stimulated to 4,000 pg/ml after a standard meal. The diarrhea decreased after partial pancreatectomy. Diffuse pancreatic islet cell hyperplasia was present and, although GIP was unmeasureable in the pancreas of normal subjects, it was at least 83 ng/g wet weight in this patient. Postoperatively, the patient's diarrhea responded dramatically to the oral administration of nicotinic acid.

References

Mar 1, 1979·Journal of Clinical Gastroenterology·M Donowitz
Oct 13, 1977·The New England Journal of Medicine·B M JaffeM Greider
May 1, 1978·The Journal of Clinical Investigation·N TurjmanT R Hendrix
Apr 1, 1978·The American Journal of Digestive Diseases·J D Gardner
Jun 1, 1976·The Journal of Surgical Research·J R FletcherC M Herman
Jan 1, 1977·American Journal of Surgery·A M EbeidJ E Fischer
Jun 1, 1977·Metabolism: Clinical and Experimental·T M O'DorisioS Cataland
Sep 1, 1976·The American Journal of Digestive Diseases·T M O'DorisioE L Mazzaferri
Dec 1, 1975·The American Journal of Digestive Diseases·M Donowitz, H J Binder
Mar 1, 1975·The American Journal of Digestive Diseases·N EinsteinH Wolfe
Jan 2, 1975·Biochemical and Biophysical Research Communications·E StrausR S Yalow
May 1, 1976·The Journal of Clinical Endocrinology and Metabolism·J L BothaJ C Brown
Apr 22, 1972·Lancet·G O BarbezatI N Marks
Oct 22, 1971·Science·G O Barbezat, M I Grossman
Sep 1, 1958·The American Journal of Medicine·J V VERNER, A B MORRISON
Jul 1, 1963·The Journal of Clinical Investigation·R H UNGERL L MADISON

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Citations

May 12, 2012·International Journal of Endocrinology·Elena TarabraMichael Khan
Nov 3, 2010·Annals of the New York Academy of Sciences·Jeremy A Lavine, Alan D Attie
Jul 15, 2015·World Journal of Gastroenterology : WJG·Wei Han, Huan-Min Wang
Apr 12, 2017·Current Gastroenterology Reports·Lawrence R Schiller
Jan 1, 1982·Acta diabetologica latina·B BeckG Debry

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