Mild cognitive impairment: an overview.

CNS Spectrums
Ronald C Petersen, Selamawit Negash

Abstract

Mild cognitive impairment (MCI) refers to the transitional state between the cognitive changes of normal aging and very early dementia. MCI has generated a great deal of research from both clinical and research perspectives. Several population- and community-based studies have documented an accelerated rate of progression to dementia and Alzheimer's disease in individuals diagnosed with MCI. Clinical subtypes of MCI have been proposed to broaden the concept and include prodromal forms of a variety of dementias. An algorithm is presented to assist the clinician in identifying subjects and subclassifying them into the various types of MCI. Progression factors, including genetic, neuroimaging, biomarker, and clinical characteristics, are discussed. Neuropathological studies indicating an intermediate state between normal aging and early dementia in subjects with MCI are presented. The recently completed clinical trials as well as neuropsychological and nutritional interventions are discussed. Finally, the clinical utility of MCI, and directions for future research are proposed.

References

Jul 1, 1991·Neurology·C FlickerB Reisberg
Sep 1, 1982·The American Journal of Psychiatry·B ReisbergT Crook
Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Mar 20, 2001·Archives of Neurology·J C MorrisL Berg
Aug 9, 2003·Nature Reviews. Drug Discovery·Ronald C Petersen
Mar 3, 2004·Annals of Neurology·William E KlunkBengt Långström
Apr 14, 2004·Neurology·H FeldmanS Ferris
Jul 14, 2004·Neurology·Mary GanguliSteven T DeKosky
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Mar 3, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Leon J ThalUNKNOWN Rofecoxib Protocol 078 study group
Apr 15, 2005·The New England Journal of Medicine·Ronald C PetersenUNKNOWN Alzheimer's Disease Cooperative Study Group
Oct 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·N T AggarwalD A Bennett
Jan 13, 2006·Archives of Neurology·William R MarkesberyDavid R Wekstein
Apr 25, 2006·Lancet·Serge GauthierUNKNOWN International Psychogeriatric Association Expert Conference on mild cognitive impairment
May 10, 2006·Archives of Neurology·Ronald C PetersenEmre Kokmen
May 10, 2006·Archives of Neurology·Gregory A JichaRonald C Petersen
Aug 2, 2006·Journal of Geriatric Psychiatry and Neurology·Ronald C Petersen, John O'Brien
Dec 28, 2006·Neurology·A BusseS G Riedel-Heller

❮ Previous
Next ❯

Citations

Oct 2, 2019·Frontiers in Integrative Neuroscience·Giovanna MioniFranca Stablum
Oct 2, 2019·Frontiers in Neuroscience·Nicoletta CeraArmando Tartaro
Jan 24, 2020·Acta neurologica Belgica·Marcela Lima SilagiLeticia Lessa Mansur
Mar 1, 2017·Frontiers in Aging Neuroscience·Agustina BirbaMáximo Zimerman
Aug 27, 2019·Frontiers in Aging Neuroscience·Yingni SunHongwei Gao
May 21, 2019·Frontiers in Aging Neuroscience·Yue-Qi ZhangQi Cheng
Dec 24, 2008·Journal of Neuropathology and Experimental Neurology·Peter T NelsonWilliam R Markesbery
Aug 25, 2009·American Journal of Alzheimer's Disease and Other Dementias·Glen M DonigerHoward A Crystal
Feb 9, 2010·JAAPA : Official Journal of the American Academy of Physician Assistants·Gilbert A Boissonneault, UNKNOWN Clinical and Scientific Affairs Council of the AAPA
Nov 18, 2009·Nature Reviews. Neurology·Majid FotuhiPeter J Whitehouse
Oct 5, 2010·International Journal of Alzheimer's Disease·Philipp SpitzerJens Wiltfang
Dec 24, 2010·Toxicologic Pathology·Thomas J Montine
Jul 8, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adelaide P YiuSheena A Josselyn
Aug 27, 2010·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Norio MurayamaKiyoshi Sato
Dec 7, 2011·International Journal of Alzheimer's Disease·Philipp SpitzerHans-Wolfgang Klafki
Jul 21, 2011·Neuropsychology Review·Alberto CostaGiovanni Augusto Carlesimo
Oct 29, 2011·Der Nervenarzt·F M Reischies, F Wertenauer
Aug 21, 2012·Topics in Geriatric Rehabilitation·Nikki L HillDavid J Gill
Nov 16, 2011·Journal of Clinical and Experimental Neuropsychology·Sonia Martínez-SanchisLuis M Pallardó
Dec 12, 2012·Dementia and Geriatric Cognitive Disorders·Anja H SimonsenGunhild Waldemar
Jul 28, 2012·Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Österreichischer Nervenärzte und Psychiater·Elisabeth M WeissEberhard A Deisenhammer
Apr 5, 2013·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Norio MurayamaKiyoshi Sato
Jul 12, 2014·American Journal of Alzheimer's Disease and Other Dementias·Christine M BeldenMarwan N Sabbagh
Dec 3, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Marcus MeinzerAgnes Flöel
Jul 16, 2015·Behavioural Neurology·Michelangelo Stanzani MaseratiRoberto Gallassi
Jan 19, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Stefan TeipelOliver K Burmeister
Nov 21, 2015·The Spanish Journal of Psychology·Herminia PeraitaRosario Martínez-Arias
Apr 12, 2016·Frontiers in Aging Neuroscience·Gábor CsuklyÁdám Szabó
Oct 7, 2015·Frontiers in Cellular Neuroscience·Kristin Prehn, Agnes Flöel
Apr 16, 2016·Journal of Alzheimer's Disease : JAD·Marta Ramos-GoicoaMontserrat Zurrón
Mar 17, 2016·American Journal of Alzheimer's Disease and Other Dementias·Shuang-Qing ChenZhong Zhao
Apr 27, 2016·Translational Psychiatry·W K W LauA C K Law

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.