Mild cognitive impairment in Parkinson's disease: the Parkinson's disease cognitive study (PACOS)

Journal of Neurology
Roberto MonasteroAlessandra Nicoletti

Abstract

Approximately 30% of Parkinson's disease (PD) patients show impaired cognitive performance, which is suggestive of Mild Cognitive Impairment (MCI), representing a predictor of dementia, especially when present at diagnosis. The objective of the study was to evaluate the frequency and clinical predictors of MCI in a large hospital-based cohort of PD patients. We collected cross-sectional data from the Parkinson's disease cognitive impairment study (PACOS), a multicenter study involving two Movement Disorder centers, which are located in south Italy. The PD subjects were diagnosed according to the UK Brain Bank criteria and they underwent an extensive neuropsychological assessment. PD-MCI was diagnosed according to the Movement Disorder Society task force criteria for MCI. PD severity was evaluated in accordance with the Unified PD Rating Scale-Motor Examination (UPDRS-ME) and the Hoehn and Yahr scales. The study included 659 PD patients (57.5% men; mean age 67.0 ± 9.7 years), with a mean disease duration of 3.8 ± 4.6 years and a mean UPRDS-ME score of 25.8 ± 12.3. PD-MCI was diagnosed in 261 (39.6%) subjects and in 82 (31.7%) of 259 newly diagnosed patients (disease duration ≤ 1 year). An amnestic MCI multidomain phenotype was t...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jun 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·W R Gibb, A J Lees
May 1, 1967·Neurology·M M Hoehn, M D Yahr
Jun 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·C P HughesR L Martin
Aug 1, 1996·Italian Journal of Neurological Sciences·A R GiovagnoliE Capitani
Sep 21, 1963·JAMA : the Journal of the American Medical Association·S KATZM W JAFFE
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Jul 5, 2005·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·I AppollonioP Nichelli
Mar 31, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Anette SchragChristopher G Goetz
Jun 2, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Murat EmreBruno Dubois
Nov 21, 2008·Neurology·D AarslandUNKNOWN Norwegian ParkWest Study Group
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Jun 11, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Irene LitvanDaniel Weintraub
Nov 16, 2011·Journal of Clinical and Experimental Neuropsychology·Paolo CaffarraAnnalena Venneri
Jan 26, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Irene LitvanMurat Emre
Mar 9, 2012·Neuro-degenerative Diseases·Roberto MonasteroCecilia Camarda
Oct 6, 2012·Neuro-degenerative Diseases·Angie A KehagiaTrevor W Robbins
Mar 23, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Connie MarrasSarah Duff-Canning
Jun 20, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Caroline H Williams-GrayRoger A Barker
Jun 25, 2013·Neurology·M BroedersB Schmand
Oct 15, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Jennifer G GoldmanGlenn T Stebbins
Dec 24, 2013·Neurology·Alison J YarnallUNKNOWN ICICLE-PD Study Group
Jan 8, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Michele T M HuYoav Ben-Shlomo
Apr 9, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Brenna A CholertonKaren L Edwards
Aug 31, 2014·Neurology·Julius B M AnangRonald B Postuma
Sep 1, 2015·Parkinsonism & Related Disorders·Gabriella SantangeloPaolo Barone
Mar 10, 2016·Parkinsonism & Related Disorders·Emanuele CeredaGianni Pezzoli
Jul 13, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Elke KalbeRichard Dodel
Sep 22, 2016·Scientific Reports·Blake J LawrenceAndrea M Loftus
Mar 4, 2017·Nature Reviews. Neurology·Dag AarslandClive Ballard
Jun 13, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Jeroen HooglandUNKNOWN MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”
Feb 18, 2016·NPJ Parkinson's Disease·Santiago Perez-Lloret, Francisco J Barrantes

❮ Previous
Next ❯

Citations

Aug 3, 2018·American Journal of Alzheimer's Disease and Other Dementias·Sukanya Jongsiriyanyong, Panita Limpawattana
May 24, 2019·The Journal of Neuropsychiatry and Clinical Neurosciences·Andreea L SeritanJill L Ostrem
Nov 20, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Chiara BaianoGabriella Santangelo
Nov 24, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Nacim BetrouniKathy Dujardin
Jul 2, 2019·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Andrea GalbiatiLuigi Ferini-Strambi
Sep 2, 2020·International Journal of Geriatric Psychiatry·Catherine PenningtonCraig Ritchie
Jan 31, 2019·Frontiers in Neurology·Antonina LucaMario Zappia
Nov 30, 2019·Frontiers in Aging Neuroscience·Davide Maria CammisuliCarlo Pruneti
Feb 26, 2019·Frontiers in Aging Neuroscience·Alessandra NicolettiRoberto Monastero
Mar 26, 2019·Journal of Alzheimer's Disease : JAD·Roberta BaschiRoberto Monastero
Aug 28, 2020·Frontiers in Neurology·Ana Simon-GozalboPablo Martinez-Martin
Jan 16, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Giulia DonzusoAlessandra Nicoletti
Feb 28, 2021·Scientific Reports·Kyoungwon BaikSuk Yun Kang
Mar 5, 2021·Journal of the International Neuropsychological Society : JINS·Helena S MoreiraCésar F Lima
Apr 4, 2021·Biosensors·Jiancheng Mo, Ronny Priefer
Apr 17, 2021·Neuropsychology Review·Elizabeth R WallaceLisa M Koehl
Feb 10, 2021·Harvard Review of Psychiatry·Alan A Baumeister
Jul 3, 2021·Brain Sciences·Paola FeracoRoberto Monastero
Jul 27, 2021·Annals of Clinical and Translational Neurology·Hailing LiuQing Wang
Jan 14, 2022·Journal of Neural Transmission·Antonina LucaAlessandra Nicoletti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical and Experimental Neuropsychology
Iván GaltierJosé Barroso
Movement Disorders : Official Journal of the Movement Disorder Society
Jennifer G GoldmanGlenn T Stebbins
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Ya-qin WangJi-feng Guo
© 2022 Meta ULC. All rights reserved