Mild cognitive impairment is a syndrome defined as cognitive decline greater than expected for an individual's age and education level but that does not interfere notably with activities of daily life. Prevalence in population-based epidemiological studies ranges from 3% to 19% in adults older than 65 years. Some people with mild cognitive impairment seem to remain stable or return to normal over time, but more than half progress to dementia within 5 years. Mild cognitive impairment can thus be regarded as a risk state for dementia, and its identification could lead to secondary prevention by controlling risk factors such as systolic hypertension. The amnestic subtype of mild cognitive impairment has a high risk of progression to Alzheimer's disease, and it could constitute a prodromal stage of this disorder. Other definitions and subtypes of mild cognitive impairment need to be studied as potential prodromes of Alzheimer's disease and other types of dementia.
Associated Clinical Trials
"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician
Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
The Gospel Oak Study stage IV: the clinical relevance of subjective memory impairment in older people
Prediction of probable Alzheimer's disease in memory-impaired patients: A prospective longitudinal study
Association of subjective memory complaints with subsequent cognitive decline in community-dwelling elderly individuals with baseline cognitive impairment
Functional impairment in instrumental activities of daily living: an early clinical sign of dementia?
Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease
Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology
Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease
Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study
Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's disease
Prediction of transition from cognitive impairment to senile dementia: a prospective, longitudinal study
Contribution of informant and patient ratings to the accuracy of the mini-mental state examination in predicting probable Alzheimer's disease
Long-term improvements in cognitive performance through computer-assisted cognitive training: a pilot study in a residential home for older people
Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia
Value of CSF beta-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment
Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials
Use of Alzheimer disease biomarkers: potentially yes for clinical trials but not yet for clinical practice
Beyond the neurotransmitter-focused approach in treating Alzheimer's disease: drugs targeting beta-amyloid and tau protein
Probing the mechanism of saccade-associated head movements through observations of head movement propensity and cognition in the elderly
Quantitative multivoxel proton MR spectroscopy study of brain metabolites in patients with amnestic mild cognitive impairment: a pilot study
Aspects of the report of the IQWiG (Institute for Quality and Cost Effectiveness in Public Health) " Cholinesterase inhibitors in Alzheimer's dementia"
Development of classification models for early identification of persons at risk for persistent cognitive decline
Clinical predictors of cognitive decline in patients with mild cognitive impairment: the Chongqing aging study
Predictive value of MoCA in the acute phase of stroke on the diagnosis of mid-term cognitive impairment
Neuroanatomic changes and their association with cognitive decline in mild cognitive impairment: a meta-analysis
Prospective comparison of the prognostic utility of the Mini Mental State Examination and the Montreal Cognitive Assessment in patients with brain metastases
Monte Carlo feature selection and rule-based models to predict Alzheimer's disease in mild cognitive impairment
Chinese herbal medicine for Mild Cognitive Impairment and Age Associated Memory Impairment: a review of randomised controlled trials
Is childhood meat eating associated with better later adulthood cognition in a developing population?
A 18F-labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography
Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes
Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial
A survey of attitudes of clinicians towards the diagnosis and treatment of mild cognitive impairment in Australia and New Zealand
Current evidence for subjective cognitive impairment (SCI) as the pre-mild cognitive impairment (MCI) stage of subsequently manifest Alzheimer's disease
What explains variations in the clinical use of mild cognitive impairment (MCI) as a diagnostic category?
Developing new treatments for Alzheimer's disease: the who, what, when, and how of biomarker-guided therapies
Multiple cognitive deficits in patients during the mild cognitive impairment stage of Alzheimer's disease: how are cognitive domains other than episodic memory impaired?
The validation of the Italian version of the GPCOG (GPCOG-It): a contribution to cross-national implementation of a screening test for dementia in general practice
Early intervention for cognitive decline: can cognitive training be used as a selective prevention technique?
Risk of progression from mild memory impairment to clinically diagnosable Alzheimer's disease in a Japanese community (from the Nakayama Study)
Functional impairment as a defining feature of: amnestic MCI cognitive, emotional, and demographic correlates
Benefits of training working memory in amnestic mild cognitive impairment: specific and transfer effects
Multi-state Markov model in outcome of mild cognitive impairments among community elderly residents in Mainland China
Factors affecting subjective memory complaints in the AIBL aging study: biomarkers, memory, affect, and age
Anosognosia in mild cognitive impairment: Relationship to activation of cortical midline structures involved in self-appraisal
Epidemiology of Aging
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