Mild Concussion, but Not Moderate Traumatic Brain Injury, Is Associated with Long-Term Depression-Like Phenotype in Mice

PloS One
Nikita M BajwaAndré Obenaus

Abstract

Mild traumatic brain injuries can lead to long-lasting cognitive and motor deficits, increasing the risk of future behavioral, neurological, and affective disorders. Our study focused on long-term behavioral deficits after repeated injury in which mice received either a single mild CHI (mCHI), a repeated mild CHI (rmCHI) consisting of one impact to each hemisphere separated by 3 days, or a moderate controlled cortical impact injury (CCI). Shams received only anesthesia. Behavioral tests were administered at 1, 3, 5, 7, and 90 days post-injury (dpi). CCI animals showed significant motor and sensory deficits in the early (1-7 dpi) and long-term (90 dpi) stages of testing. Interestingly, sensory and subtle motor deficits in rmCHI animals were found at 90 dpi. Most importantly, depression-like behaviors and social passiveness were observed in rmCHI animals at 90 dpi. These data suggest that mild concussive injuries lead to motor and sensory deficits and affective disorders that are not observed after moderate TBI.

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Citations

Nov 19, 2017·Journal of Neurotrauma·McKenzie DaviesStuart H Friess
Apr 13, 2018·Journal of Neurotrauma·Amandine JullienneAndré Obenaus
Jul 17, 2020·Frontiers in Molecular Neuroscience·Lorraine SieboldStephen Ashwal
Mar 26, 2019·Journal of Neurotrauma·Sandy R ShultzRichelle Mychasiuk
Jan 18, 2019·Experimental Neurology·Akram ZamaniBridgette D Semple
Oct 15, 2020·Journal of Neurotrauma·Juliana PopovitzHita Adwanikar

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