Mild experimental autoimmune encephalitis as a tool to induce blood-brain barrier dysfunction.

Journal of Neural Transmission
Michael K BoettgerClaudia Sommer

Abstract

The blood-brain barrier (BBB) serves as a border limiting access of immunoglobulins from the circulation into the brain. This becomes relevant when studying the pathogenesis of antibody-mediated autoimmune CNS disorders. Here, we characterized the BBB dysfunction in a model of mild experimental adoptive transfer autoimmune encephalomyelitis (AT-EAE). We show that large molecules can readily penetrate the BBB between days 3 and 7 after EAE-induction. This model may be valuable for studying putative pathogenic effects of immunoglobulins in the central nervous system.

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Citations

Jun 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Guang YangWen-Biao Gan
Oct 15, 2010·Journal of Neuroimmunology·Trygve Holmøy, Christian Geis
Jul 24, 2013·Experimental Neurology·Lea Rozenstein-TsalkovichHanna Rosenmann
Apr 21, 2016·Antibodies·Carolin HoffmannPilar Martinez-Martinez
Oct 18, 2020·Cells·Diego FresegnaAntonietta Gentile

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