PMID: 16645445Apr 29, 2006Paper

Mild hypercapnia increases subcutaneous and colonic oxygen tension in patients given 80% inspired oxygen during abdominal surgery

Anesthesiology
Edith FleischmannAndrea Kurz

Abstract

Supplemental perioperative oxygen increases tissue oxygen tension and decreases incidence of wound infection in colorectal surgery patients. Mild intraoperative hypercapnia also increases subcutaneous tissue oxygen tension. However, the effect of hypercapnia in patients already receiving supplemental oxygen is unknown, as is the effect of mild hypercapnia on intestinal oxygenation in humans-although the intestines are presumably the tissue of interest for colon surgeries. The authors tested the hypothesis that mild intraoperative hypercapnia increases both subcutaneous tissue and intramural intestinal oxygen tension in patients given supplemental oxygen. Patients undergoing elective colon resection were randomly assigned to normocapnia (n = 15, end-tidal carbon dioxide tension 35 mmHg) or mild hypercapnia (n = 15, end-tidal carbon dioxide tension 50 mmHg). Intraoperative inspired oxygen concentration was 80%. The authors measured subcutaneous tissue oxygen tension in the right upper arm and intramural oxygen tension in the left colon. Measurements were averaged over time within each patient and, subsequently, among patients. Data were compared with chi-square, unpaired t, or Mann-Whitney rank sum tests; P < 0.05 was significant...Continue Reading

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Citations

Jun 16, 2010·Der Anaesthesist·M DavidK Markstaller
Jun 26, 2008·Intensive Care Medicine·Ingo SchwartgesOlaf Picker
Nov 26, 2009·British Journal of Anaesthesia·T N WeingartenJ Sprung
Jul 28, 2013·British Journal of Anaesthesia·O AkçaUNKNOWN Hypercapnia Trial Investigators
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May 24, 2008·Anesthesia and Analgesia·Mohamed H BakriSteven R Insler
Nov 24, 2011·Anesthesiology Research and Practice·Megan Way, Gary E Hill
Feb 14, 2009·Journal of Clinical Monitoring and Computing·Murali ChakravarthyVivek Jawali
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Jul 9, 2010·European Journal of Anaesthesiology·David B WaxSteven B Porter
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Apr 2, 2009·Journal of Evaluation in Clinical Practice·Ahmed Al-Niaimi, Nasia Safdar
Jul 23, 2015·British Journal of Anaesthesia·V De Santis, M Singer
Apr 23, 2015·British Journal of Anaesthesia·A KurzUNKNOWN Factorial Trial Investigators
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Oct 24, 2008·Anesthesiology·Pierre Michelet
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Aug 7, 2021·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Li DongYosuke Yamamoto

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