Mild hyperhomocysteinemia, C677T polymorphism on methylenetetrahydrofolate reductase gene and the risk of macroangiopathy in type 2 diabetes: a prospective study

Acta Diabetologica
Giuseppina Tiziana RussoDomenico Cucinotta

Abstract

The role of hyperhomocysteinemia as a risk factor for diabetic long-term complications has not been sufficiently evaluated in prospective studies, considering specific correlates of homocysteine (tHcy) concentration and traditional cardiovascular disease (CVD) risk factors. Fasting tHcy, vitamin B12 and folate plasma levels, the common methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, as well as clinical and lifestyle information were assessed in 216 type 2 diabetic patients attending two outpatient clinics, who had a follow-up evaluation at 65 ± 9 months for the incidence of macroangiopathy. At basal evaluation, mild hyperhomocysteinemia (tHcy ≥ 15 μmol/l) was diagnosed in 21.3% of participants. At follow-up, hyperhomocysteinemia and the distribution of MTHFR C677T genotype did not significantly differ according to the incidence of macroangiopathy. Multiple variables adjusted ORs (95% CI) for CVD associated with mild hyperhomocysteinemia were 1.01 (0.37-2.82); P > 0.05; those associated with MTHFR TT genotype were 0.46 (0.15-1.38); P > 0.05. Although the prevalence of hyperhomocysteinemia was higher in diabetic men (26.9%) than in women (16.1%; P > 0.05), similar results were also observed in a separate sex-...Continue Reading

References

Jan 4, 1998·Journal of Internal Medicine·E K HoogeveenC D Stehouwer
Apr 16, 1998·The New England Journal of Medicine·G N Welch, J Loscalzo
Sep 29, 1999·Journal of Thrombosis and Thrombolysis·A MazzaC Cortese
Jun 27, 2000·Diabetes Care·A PassaroA Solini
Aug 2, 2000·The American Journal of Clinical Nutrition·L Brattström, D E Wilcken
Aug 2, 2000·The American Journal of Clinical Nutrition·P M UelandS E Vollset
Mar 10, 2001·The American Journal of Clinical Nutrition·P F JacquesJ Selhub
Dec 4, 2001·Atherosclerosis·M C Audelin, J Genest
Oct 22, 2002·JAMA : the Journal of the American Medical Association·Mariska KlerkUNKNOWN MTHFR Studies Collaboration Group
Jun 5, 2003·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·G HasegawaN Nakamura
Mar 18, 2004·European Journal of Clinical Investigation·G T RussoD Cucinotta
Jun 24, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·UNKNOWN DAI Study Group
Jan 31, 2006·American Heart Journal·UNKNOWN B-Vitamin Treatment Trialists' Collaboration
Mar 15, 2006·The New England Journal of Medicine·Eva LonnUNKNOWN Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators
May 17, 2006·The Journal of Nutrition·Jacob Selhub
Jul 4, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Gjin NdrepepaAlbert Schömig
Feb 10, 2007·Diabetes Care·Angelo AvogaroUNKNOWN Diabetes and Informatics Study Group, Association of Clinical Diabetologists, Istituto Superiore di Sanità
Aug 19, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ting-Yuan David ChengChi Pang Wen
Sep 11, 2008·Diabetes Care·Carlo B GiordaUNKNOWN Diabetes and Informatics Study Group

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Citations

Oct 1, 2011·Experimental Diabetes Research·Ganesh ChauhanDwaipayan Bharadwaj
Jul 14, 2010·Cardiology Clinics·Dan Farbstein, Andrew P Levy
Oct 26, 2016·International Journal of Cardiology·Asma Amrani-MidounNabila Bouatia-Naji
Apr 19, 2018·Diabetes/metabolism Research and Reviews·Giuseppina T RussoUNKNOWN BetaDecline Study Group
Feb 8, 2018·Current Vascular Pharmacology·Sara Mankoč Ramuš, Daniel Petrovič
Mar 30, 2012·PloS One·Abdelmajid EloualidHassan Rouba
Nov 28, 2017·British Journal of Pharmacology·Gabriele PizzinoAlessandra Bitto
Sep 22, 2017·International Journal of Endocrinology·Marwan A AhmedPaul Rheeder
Mar 24, 2017·Diabetology & Metabolic Syndrome·Daniel E PlattPierre A Zalloua
Jan 4, 2017·International Journal of Endocrinology·Giuseppina T RussoDomenico Cucinotta

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