Mild hyperhomocysteinemia is associated with a decreased fibrinolytic activity in patients after ST-elevation myocardial infarction

Thrombosis Research
Walter Stefan SpeidlKurt Huber

Abstract

Elevated homocysteine (Hcy) levels have been associated with increased risk for cardiovascular disease and it has been shown that hyperhomocysteinemia is associated with increased levels of t-PA antigen in individuals without evidence for coronary artery disease (CAD). The aim of this study was to examine if Hcy plasma levels are associated with plasma levels of fibrinolytic factors in patients with CAD and a history of acute myocardial infarction. We measured in 56 patients with CAD, 1 month after their first ST-elevation myocardial infarction, plasma levels of Hcy, the fibrinolytic parameters tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-type-1 (PAI-1), and t-PA-PAI-1 complexes. Hcy plasma levels inversely correlated with t-PA activity (r=-0.303, p<0.05). Patients with mild hyperhomocysteinemia (Hcy>15 micromol/L, n=8) showed significantly lower plasma levels of t-PA activity (p<0.05). Regression analysis revealed that out of cardiovascular risk factors and medical treatment only Hcy was significantly associated with t-PA activity. Patients with CAD after a first myocardial infarction and hyperhomocysteinemia show a reduced t-PA activity independently from cardiovascular risk factors and medical tr...Continue Reading

References

Jan 1, 1992·Annual Review of Nutrition·S S KangM R Malinow
May 1, 1992·Atherosclerosis·A D Blann
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·J C TsaiM E Lee
Sep 26, 1996·The New England Journal of Medicine·M CattaneoP M Mannucci
Dec 31, 1997·The New England Journal of Medicine·S Moll
Apr 16, 1998·The New England Journal of Medicine·G N Welch, J Loscalzo
May 21, 1998·Journal of Cardiovascular Pharmacology·P AndersenI Holme
Jan 5, 2002·The New England Journal of Medicine·G SchnyderO M Hess
Nov 24, 2004·Journal of Internal Medicine·J HultdinG Hallmans

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.