Mild hyperthermia promotes and accelerates development and maturation of erythroid cells

Stem Cells and Development
Fatoumata Korika TounkaraNicolas Pineault

Abstract

Hyperthermia treatment has at times been associated with increased platelet levels in humans. The heat shock protein HSP70, which can be induced by hyperthermia in megakaryocytes and erythrocytes, was recently shown to protect GATA-1 from degradation and to be required for erythroid differentiation. Based on these findings, we hypothesize that mild hyperthermia (MH), such as fever (39°C), could impact the differentiation of hematopoietic progenitors into erythrocytes and their subsequent maturation. Cell growth and erythroid differentiation increased dramatically in cord blood CD34(+) cell cultures incubated under MH. Erythroid maturation was also strongly promoted, which resulted in an increased proportion of hemoglobinized and enucleated erythroids. The rise in erythroid development was traced to a strong synergistic activity between MH and erythropoietin (EPO). The molecular basis for this potent synergy appears to originate from the capacity of MH to increase the basal activation of several signaling molecules downstream of the EPO receptor and the transcriptional activity of GATA-1. Moreover, the potent impact of MH on erythroid development was found be dependent on increased intracellular levels of reactive oxygen species...Continue Reading

References

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Citations

Jul 15, 2015·Bioinorganic Chemistry and Applications·Yuanyuan ZhangFan Jiang

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Methods Mentioned

BETA
flow cytometry
Assay
FCS
Protein Assay

Software Mentioned

GraphPad InStat
FCS Express

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