Mild hypothermia reduces acute mortality and improves hemodynamic outcome in a cardiogenic shock pig model

Resuscitation
Matthias GötbergDavid Erlinge

Abstract

Cardiogenic shock is the main cause of death in patients hospitalized due to an acute myocardial infarction. Mild hypothermia reduces metabolism and could offer protective effects for this condition. The aim of our study was to investigate if mild therapeutic hypothermia would improve outcome and hemodynamic parameters in an ischemic cardiogenic shock pig model. Twenty-five pigs (40-50 kg) were anesthetized and a normothermic temperature of 38 degrees C was established utilising an endovascular cooling catheter in a closed-chest model. A Swan-Ganz catheter was placed in the pulmonary artery. Hemodynamic parameters were continuously monitored and blood gases were sampled every 30 min. Ischemia was induced by inflation of a PCI balloon in proximal LAD for 40 min. Sixteen pigs that have fulfilled predefined shock criteria were randomized to hypothermia (n=8), or normothermia (n=8). Hypothermia (33 degrees C) was induced after onset of reperfusion by using an endovascular temperature modulating catheter and was maintained until termination of the experiment. The pigs in the hypothermia group were cooled to <34 degrees C in approximately 45 min. 5/8 pigs in the normothermia group died while all pigs in the hypothermia group survived...Continue Reading

References

Apr 1, 1983·Journal of the American College of Cardiology·R V HaendchenM C Fishbein
Jan 1, 1995·American Journal of Respiratory and Critical Care Medicine·C A ManthousL D Wood
May 1, 2001·Basic Research in Cardiology·J WeisserB Pieske
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Michael W DaeCarol A Stillson
Sep 24, 2005·Basic Research in Cardiology·Michael MaengHenning R Andersen
Aug 3, 2007·Interactive Cardiovascular and Thoracic Surgery·Yoshiharu NishimuraYoshitaka Okamura

❮ Previous
Next ❯

Citations

Oct 25, 2011·Critical Care : the Official Journal of the Critical Care Forum·Christoph TestoriBernd Jilma
Apr 5, 2011·Current Opinion in Critical Care·Kjetil Sunde, Eldar Søreide
Dec 31, 2010·Journal of Thrombosis and Thrombolysis·Jesper van der PalsDavid Erlinge
Dec 2, 2011·Cardiovascular Research·Renaud TissierAlain Berdeaux
Jun 16, 2011·Basic Research in Cardiology·Matthias GötbergDavid Erlinge
Nov 28, 2013·Heart Failure Clinics·Massimo MassettiFranco Cavaliere
Apr 30, 2014·Revista Española De Cardiología·Kjetil Sunde
Oct 10, 2012·Resuscitation·Stephan Schmidt-SchwedaBurkert Pieske
Dec 14, 2011·Resuscitation·Xinrong HeJean-Louis Vincent
Mar 5, 2016·Medizinische Klinik, Intensivmedizin und Notfallmedizin·V MezgerM Sander
Jul 30, 2015·Therapeutic Hypothermia and Temperature Management·David J L ZughaftMatthias Götberg
Jan 14, 2012·Journal of the American College of Cardiology·Cédric DelhayeRon Waksman
Jan 11, 2014·Progress in Neurobiology·Fan ChenXunming Ji
Oct 22, 2011·The Journal of Thoracic and Cardiovascular Surgery·Alessio RungatscherGiuseppe Faggian
Feb 27, 2016·Therapeutic Hypothermia and Temperature Management·Françoise ArnaudRichard McCarron
Aug 13, 2014·European Heart Journal. Acute Cardiovascular Care·Brian StegmanVenu Menon
Dec 31, 2015·European Heart Journal. Acute Cardiovascular Care·Luis O ChavezJoseph Varon
Dec 18, 2013·European Heart Journal. Acute Cardiovascular Care·Chiara LazzeriSerafina Valente
Jun 22, 2018·Acta Anaesthesiologica Scandinavica·J DüringH Friberg
May 17, 2018·Angiogenesis·Patrycja Nowak-SliwinskaArjan W Griffioen
Oct 7, 2017·Internal and Emergency Medicine·Yuan YaoDavid Foster Gaieski
Jan 1, 2011·Therapeutic Hypothermia and Temperature Management·David Erlinge
Jan 1, 2011·Therapeutic Hypothermia and Temperature Management·Simon DixonDavid Erlinge
Nov 19, 2017·Journal of the American Heart Association·Joseph S PiktelLance D Wilson
Jul 22, 2018·Circulation·Georg FuernauHolger Thiele
Aug 22, 2013·Critical Care Medicine·Michael SchwarzlHeiner Post
Sep 26, 2019·Frontiers in Cardiovascular Medicine·Joseph S Piktel, Lance D Wilson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiogenic Shock

Cardiogenic shock is a devastating consequence of acute myocardial infarction and is associated with an extremely high mortality. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.