Mild hypoxic ischaemic encephalopathy and long term neurodevelopmental outcome - A systematic review

Early Human Development
J M ConwayDeirdre M Murray

Abstract

Hypoxic ischaemic encephalopathy (HIE) remains a significant cause of long term neurodisability despite therapeutic hypothermia (TH). Infants with mild HIE, representing 50% of those with HIE, are perceived as low risk and are currently not eligible for TH [1]. This review examines the available evidence of outcome in term infants with mild HIE. Medline, Embase and Cochrane Clinical Trials databases were searched in March 2017. Studies with well-defined HIE grading at birth and standardised neurodevelopmental assessment at ≥18 months were included. Abnormal outcome was defined as death, cerebral palsy or standardised neurodevelopmental test score more than 1 standard deviation below the mean. Twenty studies were included. Abnormal outcome was reported in 86/341 (25%) of infants. There was insufficient evidence to examine the effect of TH on outcome. A significant proportion of infants with mild HIE have abnormal outcome at follow up.

Citations

Mar 23, 2019·Journal of Child Neurology·Chia L SawSanjay Patole
Dec 6, 2018·Endocrine, Metabolic & Immune Disorders Drug Targets·Adel A HagagAmal E Abd El-Latif
Dec 28, 2019·Developmental Medicine and Child Neurology·Michael Fahey
Dec 21, 2018·Archives of Disease in Childhood. Fetal and Neonatal Edition·Ujwal KariholuSudhin Thayyil
Dec 12, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·Megan DibbleArun Lawrence Warren Bokde
Jul 29, 2020·Molecular Neurobiology·Sophie CaseyDeirdre M Murray
Oct 24, 2018·Pediatric Research·Dalit Cayam-Rand, Steven P Miller
Nov 27, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Laura PerrettaJeffrey Perlman
Jan 15, 2019·Current Neurology and Neuroscience Reports·Guido WassinkAlistair J Gunn
Dec 12, 2019·Frontiers in Pediatrics·Anup C KatheriaSatyan Lakshminrusimha
Jun 6, 2020·Frontiers in Pediatrics·Mary O'DeaEleanor J Molloy
Oct 30, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Lili LiuJunya Chen
Mar 10, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·Lara ShipleyDon Sharkey
Sep 30, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·A Garcia-AlixUNKNOWN Grupo Cerebro Neonatal
Apr 8, 2021·Pediatric Research·Thiviya Selvanathan, Steven P Miller
Mar 15, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Megan W BerubeRyan M McAdams
May 5, 2021·Acta Paediatrica·Zunera ZareenEleanor J Molloy
Jun 20, 2021·Seminars in Fetal & Neonatal Medicine·Hemmen SabirUNKNOWN Newborn Brain Society Guidelines and Publications Committee
Jul 17, 2021·Neural Regeneration Research·Alice McDouallJoanne O Davidson
Aug 1, 2021·Seminars in Fetal & Neonatal Medicine·Neil MarlowUNKNOWN Newborn Brain Society Guidelines and Publications Committee
Aug 16, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Brian H WalshMohamed El-Dib
Sep 1, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·Leah YiehJoel Hay
Sep 1, 2021·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Nuria Torre MonmanyElisabeth Esteban
Oct 7, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ashok BuchiboyinaShailender Mehta
Oct 3, 2021·Acta Paediatrica·Anna KiviLeena Haataja

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
R M PresslerJ M Rennie
The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Bhawandeep GargAnju Bansal
© 2022 Meta ULC. All rights reserved