Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity

Physiological Genomics
Derick G WansinkWiljan Hendriks

Abstract

Mouse PTP-BL is a large, nontransmembrane protein tyrosine phosphatase of unclear physiological function that consists of a KIND domain, a FERM domain, five PDZ domains, and a COOH-terminal catalytic PTP domain. PTP-BL and its human ortholog PTP-BAS have been proposed to play a role in the regulation of microfilament dynamics, cytokinesis, apoptosis, and neurite outgrowth. To investigate the biological function of PTP-BL enzyme activity, we have generated mice that lack the PTP-BL PTP moiety. These PTP-BL(DeltaP/DeltaP) mice are viable and fertile and do not present overt morphological alterations. Although PTP-BL is expressed in most hematopoietic cell lineages, no alterations of thymocyte development in PTP-BL(DeltaP/DeltaP) mice could be detected. Sciatic nerve lesioning revealed that sensory nerve recovery is unaltered in these mice. In contrast, a very mild but significant impairment of motor nerve repair was observed. Our findings exclude an essential role for PTP-BL as a phosphotyrosine phosphatase and rather are in line with a role as scaffolding or anchoring molecule.

References

May 1, 1991·British Journal of Pharmacology·C E Van der ZeeW H Gispen
Mar 12, 1984·Brain Research·C B Jenq, R E Coggeshall
Jun 1, 1980·European Journal of Biochemistry·C Auffray, F Rougeon
Aug 20, 1982·The Journal of Comparative Neurology·M Murray
May 1, 1995·Journal of Neuroscience Methods·L de Medinaceli
Jun 30, 1995·Biochimica Et Biophysica Acta·K SteeghsB Wieringa
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·M GuP W Majerus
Jan 1, 1997·Archives of Physical Medicine and Rehabilitation·N L van MeeterenW H Gispen
Apr 4, 1998·Molecular Biology of the Cell·E CuppenW Hendriks
Jun 17, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A K VossP Gruss
Jun 17, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T ThomasP Gruss
Oct 3, 1998·Trends in Biochemical Sciences·A H ChishtiK B Hoover
Apr 5, 2000·The Journal of Biological Chemistry·K HironakaT Yamamoto
May 23, 2000·European Journal of Immunology·S HanT Mustelin
Aug 5, 2000·International Journal of Cancer. Journal International Du Cancer·Y LiT Sato
Aug 15, 2000·European Journal of Immunology·A Gjörloff-WingrenT Mustelin
Dec 6, 2000·European Journal of Biochemistry·Y NakaiT A Sato
Oct 5, 2001·Molecular and Cellular Biology·J N AndersenN P Møller
Aug 3, 2002·Nature Reviews. Molecular Cell Biology·Anthony BretscherRichard G Fehon
Sep 19, 2002·The Journal of Biological Chemistry·Yufang ZhengCarl P Blobel

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Citations

Nov 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kerstin Hofmeyer, Jessica E Treisman
Jun 4, 2005·The European Journal of Neuroscience·Barbara LorberAnn Logan
Feb 27, 2008·The FEBS Journal·Wiljan J A J HendriksAndrew W Stoker
Nov 13, 2008·International Journal of Cancer. Journal International Du Cancer·Françoise RévillionGilles Freiss
Oct 24, 2007·The European Journal of Neuroscience·Shin-ichiro KinaTadashi Yamamoto
May 28, 2013·Biochimica Et Biophysica Acta·Wiljan J A J Hendriks, Rafael Pulido
Sep 29, 2009·The International Journal of Biochemistry & Cell Biology·Murielle Glondu-LassisGilles Freiss
Sep 7, 2014·Biochimica Et Biophysica Acta·José L SardinaAngel Hernández-Hernández
Aug 14, 2008·Behavioral and Brain Functions : BBF·Claudia PatrignaniPaola F Zaratin
Nov 30, 2014·Trends in Endocrinology and Metabolism : TEM·Esteban N GurzovHelen E Thomas
Sep 16, 2014·Acta Pharmacologica Sinica·Rong-Jun HeZhong-Yin Zhang
Feb 13, 2008·Cancer Metastasis Reviews·Ogan D Abaan, Jeffrey A Toretsky
May 27, 2010·Cancer Research·Murielle Glondu-LassisGilles Freiss
Dec 17, 2020·Biomolecules·Soha McheikGilles Freiss

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