Mild, Pd-catalyzed stannylation of radioiodination targets

Bioorganic & Medicinal Chemistry Letters
Julie E PickettSusruta Majumdar

Abstract

Trialkylstannanes are versatile precursors for chemical transformations, including radiolabeling with a variety of halogens, particularly iodine. In the present work a convenient, Pd-mediated stannylation method is presented that can be performed in an open flask. The method is selective for aryl iodides allowing selective stannylations in the presence of other halogen atoms. The reaction conditions are mild, making the method compatible with chemically sensitive bioactive compounds.

References

Jan 30, 2002·Bioorganic & Medicinal Chemistry Letters·Duane A BurnettJohn W Clader
Nov 28, 2002·Nuclear Medicine and Biology·George W KabalkaJianhua Zhang
Mar 20, 2003·Journal of the American Chemical Society·Hans J ReichC Christoph Tzschucke
May 28, 2003·Nuclear Medicine and Biology·George W KabalkaJinhua Zhang
Oct 7, 2004·Nuclear Medicine and Biology·George W Kabalka, Arjun R Mereddy
May 31, 2011·Bioorganic & Medicinal Chemistry Letters·Susruta MajumdarGavril W Pasternak
Aug 11, 2011·Journal of the American Chemical Society·Chenghong HuangTobias Ritter
Nov 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Susruta MajumdarGavril W Pasternak
Aug 29, 2012·Biochemical and Biophysical Research Communications·Felix J KimGavril W Pasternak
Sep 6, 2013·Molecular Pharmacology·Joel M SchrockFelix J Kim

❮ Previous
Next ❯

Citations

Jun 6, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Kishore K GangangariNagaVara Kishore Pillarsetty

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.