Mild posttraumatic hypothermia reduces mortality after severe controlled cortical impact in rats

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
R S ClarkS T DeKosky

Abstract

The effect of posttraumatic hypothermia (brain temperature controlled at 32 degrees C for 4 h) on mortality after severe controlled cortical impact (CCI) was studied in rats. Four posttraumatic brain temperatures were compared: 37 degrees C (n = 10), 36 degrees C (n = 4), 32 degrees C (n = 10), and uncontrolled (UC; n = 6). Rats were anesthetized and subjected to severe CCI (4.0-m/s velocity, 3.0-mm depth) to the exposed left parietal cortex. At 10 min posttrauma the rats were cooled or maintained at their target brain temperature, using external cooling or warming. Brain temperature in the UC group was recorded but not regulated, and rectal temperature was maintained at 37 +/- 0.5 degrees C. After 4 h, rats were rewarmed over a 1-h period to 37 degrees C, extubated, and observed for 24 h. In the 37 and 36 degree C groups, 24-h mortality was 50% (37 degrees C = 5/10, 36 degrees C = 2/4). In the 32 degree C group, 24-h mortality was 10% (1/10). In the UC group, brain temperature was 35.4 +/- 0.6 degrees C during the 4-h treatment period and 24-h mortality was 0% (0/6). Mortality was higher in groups with brain temperatures > or = 36 degrees C versus those with brain temperatures < 36 degrees C (50 vs. 6%, respectively; p < 0.05)...Continue Reading

References

Oct 1, 1991·Journal of Neuroscience Methods·C E DixonR L Hayes
Jan 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G L CliftonR L Hayes
Jan 1, 1990·Journal of Neurotrauma·J W LighthallC R Pinderski
Jul 1, 1987·Journal of Neurosurgery·C E DixonR L Hayes
Sep 1, 1986·Clinical Pharmacology and Therapeutics·C W LoomisG D Johnson
Mar 1, 1985·Journal of Neurosurgery·J D WardR Keenan
Oct 1, 1965·Archives of Neurology·H L RosomoffJ Bebin
Nov 1, 1981·Anesthesiology·L BerntmanJ R Harp
Jan 1, 1993·Journal of Neurotrauma·G L CliftonS C Choi
Sep 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W C TaftR L Hayes
Apr 1, 1993·Molecular and Chemical Neuropathology·B G LyethL W Jenkins
Jun 1, 1993·The Annals of Thoracic Surgery·A M GillinovW A Baumgartner
Oct 1, 1954·The American Journal of Physiology·H L ROSOMOFF, D A HOLADAY

❮ Previous
Next ❯

Citations

Mar 3, 2005·Der Anaesthesist·A BrüxK H Polderman
Mar 19, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Chenkai MaJie Ma
Apr 13, 2007·European Journal of Applied Physiology·Yunjian Wang, Liang Zhu
Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·W Dalton Dietrich, Helen M Bramlett
Jun 6, 2008·The New England Journal of Medicine·James S HutchisonUNKNOWN Hypothermia Pediatric Head Injury Trial Investigators and the Canadian Critical Care Trials Group
Feb 18, 2005·Journal of Neurotrauma·Alanna J Church, R David Andrew
Mar 11, 2009·Journal of Neurotrauma·P David Adelson
Feb 28, 2009·Journal of Neurotrauma·W Dalton DietrichHelen M Bramlett
Apr 5, 2011·Therapeutic Hypothermia and Temperature Management·George LotockiHelen M Bramlett
Jul 12, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Frank W MolerJ Michael Dean
Dec 28, 2010·Neurorehabilitation and Neural Repair·Benjamin Wells de WittAnthony E Kline
Jan 5, 2002·Journal of Neurosurgery·C G MarkgrafM R Moody
May 15, 2013·Lancet Neurology·P David AdelsonUNKNOWN Paediatric Traumatic Brain Injury Consortium
Feb 11, 2004·Experimental Neurology·Takamoto SuzukiW Dalton Dietrich
Sep 24, 2013·Best Practice & Research. Clinical Anaesthesiology·Michael Holzer
Sep 1, 2006·Developmental Neuroscience·J HutchisonUNKNOWN Canadian Critical Care Trials Group
May 26, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Paul McCarthyAlireza Minagar
Oct 28, 2008·Resuscitation·Said Hachimi-Idrissi, Luc Huyghens
Jan 14, 2009·Best Practice & Research. Clinical Anaesthesiology·Michael Holzer, Wilhelm Behringer
Mar 5, 2011·Paediatric Anaesthesia·Gianluca BertolizioBruno Bissonnette
Feb 6, 1998·The American Journal of Emergency Medicine·F XiaoA Radovsky
Oct 26, 2005·Journal of Hepatology·Javier VaqueroRoger F Butterworth
Dec 8, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Harald G Fritz, Reinhard Bauer
Aug 1, 1997·Emergency Medicine Clinics of North America·T K McIntoshD H Smith
Nov 5, 2014·Neurologia Medico-chirurgica·Eiichi SuehiroMichiyasu Suzuki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
R T MansfieldP M Kochanek
© 2021 Meta ULC. All rights reserved