Mild preischemia hypothermia adversely affects postischemic myocardial function in the neonatal piglet heart

The Journal of Surgical Research
V A KellerJ J Ferrara

Abstract

During cardiac surgery, operative hypothermia has been shown to be beneficial in certain situations, although in children perioperative hypothermia has been associated with several physiologic alterations that have proven detrimental to their postoperative function. Little attention has been given to the effects of mild (34.5 degrees C) perioperative hypothermia on postischemic myocardial function in the pediatric population. It was hypothesized that mild hypothermia would be detrimental to postischemic ventricular function in the neonatal heart. Neonatal (0-2 days old) piglets were subjected to mild perioperative hypothermia without rewarming (HT-only, n = 6), hypothermia followed by rewarming (HT-RW, n = 6), or continuous normothermia (NT, n = 8). The hearts were rapidly excised, suspended on an isolated perfusion apparatus, and allowed to spontaneously beat while being perfused with an asanguinous solution. All hearts were subjected to 20 min global, normothermic, zero-flow ischemia followed by 45 min oxygenated crystallite buffer reperfusion (I-R). Compared to that of NT piglets, there were significant (P < 0.05) reductions in recovery of left ventricular (LV) diastolic and systolic function following ischemia and reperfusi...Continue Reading

References

Apr 1, 1977·Anesthesiology·E J BennettE M Grundy
Jan 1, 1992·International Anesthesiology Clinics·B Bissonnette
Feb 1, 1971·Archives of Surgery·R H Morris
Mar 1, 1973·Anesthesia and Analgesia·F A BerryC A DiFazio

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Citations

Apr 27, 2017·Therapeutic Hypothermia and Temperature Management·Junjie GuoJunbo Ge
Jul 13, 2002·The Surgical Clinics of North America·Miren Schinco, Joseph J Tepas

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