Abstract
Mild reduction in the protein content in the diet of pregnant rats from 25 to 8% casein, calorically compensated by carbohydrates, does not alter body and brain weights of rat pups at birth, but results in significant changes of the concentration and release of cortical noradrenaline during postnatal life, together with impaired long-term potentiation and memory formation. Since some central noradrenergic receptors are critically involved in neuroplasticity, the present study evaluated, by utilizing immunohistochemical methods, the effect of mild prenatal protein malnutrition on the alpha 2C-adrenoceptor expression in the frontal and occipital cortices of 8- and 60-day-old rats. At day 8 of postnatal age, prenatally malnourished rats exhibited a three-fold increase of alpha 2C-adrenoceptor expression in both the frontal and the occipital cortices, as compared to well-nourished controls. At 60 days of age, prenatally malnourished rats showed normal expression levels scores of alpha 2C-adrenoceptor in the neocortex. Results suggest that overexpression of neocortical alpha 2C-adrenoceptors during early postnatal life, subsequent to mild prenatal protein malnutrition, could in part be responsible for neural and behavioral disturban...Continue Reading
References
Jun 1, 1991·Neurochemical Research·M E Gibbs
Sep 23, 1986·European Journal of Pharmacology·D B SternbergJ L McGaugh
Jan 1, 1982·Neuroscience and Biobehavioral Reviews·O ResnickM Miller
Mar 5, 1982·Science·E A KellerO A Orsingher
Feb 22, 1993·The Journal of Comparative Neurology·A P NicholasT Hökfelt
Oct 1, 1995·Behavioral Neuroscience·M D Bunsey, B J Strupp
May 1, 1996·Histochemistry and Cell Biology·W D Sierralta, H H Thole
Feb 10, 1997·Neuroreport·C R BramhamJ M Sarvey
Nov 14, 1997·Neuroscience and Biobehavioral Reviews·J H McDonough, T M Shih
Nov 25, 1997·Brain Research. Developmental Brain Research·P GressensD Maiter
Jul 3, 1998·European Journal of Pharmacology·A HaapalinnaR Lammintausta
Apr 20, 1999·Naunyn-Schmiedeberg's Archives of Pharmacology·A HaapalinnaR Virtanen
May 21, 1999·Neuroscience·M BjörklundP Riekkinen
Apr 3, 2002·Neuroscience·M M BüchelerL Hein
Nov 5, 2003·Journal of Neurobiology·Leif Dehmelt, Shelley Halpain
Jun 7, 2005·Journal of Neurochemistry·Rubén Soto-MoyanoAlejandro Hernández
Jan 1, 1989·IEEE Transactions on Medical Imaging·D N KennedyV R Caviness
Citations
Jul 8, 2008·Neural Plasticity·Alejandro HernándezLuis Valladares
Aug 16, 2012·Neurobiology of Learning and Memory·Rafael BarraAlejandro Hernández
Apr 18, 2012·Psychiatry Research·Veronika HusarovaDusan Dobrota
May 8, 2007·Neuroscience Letters·Mario NavarreteHernán Pérez
Dec 3, 2014·Neurobiology of Learning and Memory·Patricio Sáez-BrionesAlejandro Hernández
Nov 18, 2018·Nutrition Reviews·Rafael BarraAlejandro Hernández
Dec 15, 2020·Nutritional Neuroscience·R J RushmoreD L Rosene