Mild prenatal protein malnutrition increases alpha 2C-adrenoceptor expression in the rat cerebral cortex during postnatal life

Brain Research Bulletin
Walter SierraltaR Soto-Moyano

Abstract

Mild reduction in the protein content in the diet of pregnant rats from 25 to 8% casein, calorically compensated by carbohydrates, does not alter body and brain weights of rat pups at birth, but results in significant changes of the concentration and release of cortical noradrenaline during postnatal life, together with impaired long-term potentiation and memory formation. Since some central noradrenergic receptors are critically involved in neuroplasticity, the present study evaluated, by utilizing immunohistochemical methods, the effect of mild prenatal protein malnutrition on the alpha 2C-adrenoceptor expression in the frontal and occipital cortices of 8- and 60-day-old rats. At day 8 of postnatal age, prenatally malnourished rats exhibited a three-fold increase of alpha 2C-adrenoceptor expression in both the frontal and the occipital cortices, as compared to well-nourished controls. At 60 days of age, prenatally malnourished rats showed normal expression levels scores of alpha 2C-adrenoceptor in the neocortex. Results suggest that overexpression of neocortical alpha 2C-adrenoceptors during early postnatal life, subsequent to mild prenatal protein malnutrition, could in part be responsible for neural and behavioral disturban...Continue Reading

References

Jun 1, 1991·Neurochemical Research·M E Gibbs
Sep 23, 1986·European Journal of Pharmacology·D B SternbergJ L McGaugh
Jan 1, 1982·Neuroscience and Biobehavioral Reviews·O ResnickM Miller
Feb 22, 1993·The Journal of Comparative Neurology·A P NicholasT Hökfelt
Feb 10, 1997·Neuroreport·C R BramhamJ M Sarvey
Nov 14, 1997·Neuroscience and Biobehavioral Reviews·J H McDonough, T M Shih
Nov 25, 1997·Brain Research. Developmental Brain Research·P GressensD Maiter
Jul 3, 1998·European Journal of Pharmacology·A HaapalinnaR Lammintausta
Nov 5, 2003·Journal of Neurobiology·Leif Dehmelt, Shelley Halpain
Jan 1, 1989·IEEE Transactions on Medical Imaging·D N KennedyV R Caviness

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