Mild renal dysfunction is a risk factor for a decrease in bone mineral density and vertebral fractures in Japanese postmenopausal women

The Journal of Clinical Endocrinology and Metabolism
Hiroshi KajiToshitsugu Sugimoto

Abstract

The effect of mild renal dysfunction on bone mineral density and fracture risk is uncertain. We evaluated whether mild renal dysfunction would affect bone mineral density (BMD) and the risk of vertebral fractures (VFs) in 659 postmenopausal women. Creatinine clearance (CCr) and the estimated glomerular filtration rate (eGFR) were calculated using the Cockcroft-Gault and the Modification of Diet in Renal Disease formulas, respectively. BMD was measured by dual-energy x-ray absorptiometry. Renal function was categorized by the criteria of the Kidney Disease Outcomes Quality Initiative Committee. Comparison of fracture prevalence by chronic kidney disease stages revealed that the group of stage 3 or greater by eGFR had a significantly higher rate of VFs (45.3%) than stages 1 (23.8%) and 2 (25.3%) groups. In the stage 2 group, there were significant positive correlations between eGFR and BMD values at the femoral neck and radius as well as between CCr and BMD values at all sites. Moreover, postmenopausal women with VFs had lower eGFR and CCr than those without VFs in stage 2. When multivariable logistic regression analysis was performed with the presence of VFs as a dependent variable and CCr levels adjusted for years after menopau...Continue Reading

References

Oct 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E R YendtG Rosenberg
Jan 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R Smith-BindmanH K Genant
Sep 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E R YendtG Rosenberg
Oct 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M S SteinG J Becker
Jun 8, 2000·The Journal of Clinical Endocrinology and Metabolism·D NakaokaK Chihara
Jul 8, 2000·Kidney International·A M AlemC Stehman-Breen
Nov 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M Coco, H Rush
Feb 15, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy
Aug 10, 2002·American Journal of Nephrology·Hiroshi KajiKenichi Sekita
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Josef CoreshAndrew S Levey
Jul 5, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Sidney KlawanskySusan D Ross
Jul 16, 2003·Annals of Internal Medicine·Andrew S LeveyUNKNOWN National Kidney Foundation
Sep 30, 2003·Journal of the American Society of Nephrology : JASN·Julie LinAjay K Singh
Jan 14, 2004·Kidney International·Amit X GargJoel G Ray
Jan 30, 2004·Journal of the American Society of Nephrology : JASN·Richard J LundKeith A Hruska
Jun 24, 2004·Journal of the American Society of Nephrology : JASN·Fan Fan HouXun Zhang
May 27, 2005·Journal of the American Society of Nephrology : JASN·Orlando GutierrezMyles Wolf
Jun 4, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Laurent DukasHannes B Stähelin
Sep 29, 2006·Journal of the American Society of Nephrology : JASN·Thomas L NickolasElizabeth Shane
Oct 25, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Simerjot K JassalElizabeth Barrett-Connor
Jan 24, 2007·Archives of Internal Medicine·Kristine E EnsrudUNKNOWN Osteoporotic Fractures Research Group
Jul 28, 2007·Journal of the American Society of Nephrology : JASN·Danilo FliserPeter Riegler
Dec 21, 2007·Journal of Bone and Mineral Metabolism·Masataka ShirakiToshitaka Nakamura
Jan 9, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B J EdwardsM Favus
Jan 25, 2008·Journal of the American Society of Nephrology : JASN·Tamara IsakovaMyles Wolf
Mar 28, 2008·International Urology and Nephrology·Csaba P Kovesdy, Kamyar Kalantar-Zadeh
Jun 20, 2008·Kidney International·Thomas L NickolasElizabeth Shane
Jan 29, 2009·The Journal of Clinical Endocrinology and Metabolism·Meryl S LeboffSteven Cummings
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Jun 11, 2009·Clinical and Experimental Nephrology·Enyu ImaiSeiichi Matsuo
Jun 12, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Justine BacchettaDenis Fouque
Dec 29, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Joachim H IxMary A Whooley

❮ Previous
Next ❯

Citations

Jun 1, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K E EnsrudJ A Cauley
Jun 12, 2013·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Akinori SakaiYoshifumi Fuse
Jul 4, 2015·Journal of the American Society of Nephrology : JASN·Michelle R DenburgMary B Leonard
Apr 9, 2014·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Guilherme Alcantara Cunha LimaMaria Lucia Fleiuss Farias
Jan 4, 2013·Kidney International·Lucas E NikkelUNKNOWN CURE Group (The Columbia University Renal Epidemiology Group)
Dec 27, 2011·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Christy M KingJason D Pollard
Mar 5, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Thomas L NickolasElizabeth Shane
Jul 13, 2011·The Mount Sinai Journal of Medicine, New York·Cathleen Colón-EmericElizabeth Haney
Mar 21, 2015·Calcified Tissue International·Mitsuru Saito, Keishi Marumo
Dec 20, 2017·Menopause : the Journal of the North American Menopause Society·Wen HanXiang-Mei Chen
Oct 19, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L MalmgrenK E Akesson
Sep 28, 2017·Journal of Menopausal Medicine·Byung Kyu ParkOok Hwan Choi
Nov 18, 2019·Current Osteoporosis Reports·Dorey A Glenn, Michelle R Denburg
May 25, 2016·Current Opinion in Nephrology and Hypertension·Michelle R Denburg
Feb 11, 2016·Journal of Strength and Conditioning Research·Sandra M MarinhoDenise Mafra
Jun 28, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H ChenR T de Jongh
May 9, 2019·Kidney Research and Clinical Practice·Young Eun KwonUNKNOWN ESRD Registry Committee of the Korean Society of Nephrology
Sep 7, 2020·Journal of Bone and Mineral Metabolism·Ippei KanazawaUNKNOWN from the Japan Osteoporosis Society Lifestyle diseases-related Fracture Risk Investigation Committee
Jan 19, 2013·Endocrine Journal·Ichiro TatsunoMakio Shozu
Nov 30, 2018·Physiological Research·I Zofkova, P Nemcikova
Dec 5, 2012·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Toshitsugu Sugimoto
Nov 14, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N A GotoM E Hamaker
Sep 29, 2020·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Emilio González-ParraMaría Dolores Arenas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.