Mild subclinical hypothyroidism is associated with paediatric dyslipidaemia

Clinical Endocrinology
Amanda R DahlSeema Kumar

Abstract

There is a lack of consensus on the cardiometabolic consequences of mild subclinical hypothyroidism (SCH) among children. The objective of the current study was to compare lipid profiles in children with mild SCH with those of euthyroid children. Retrospective medical record review. Children (ages 2-18 years) who had undergone simultaneous measurement of TSH, free thyroxine (T4) and lipids. Lipids in children with mild SCH (TSH 5-<10 mIU/L and normal free T4, n = 228) were compared with those in euthyroid children (n = 1215). TSH level was positively associated with total cholesterol and nonhigh density lipoprotein (non-HDL) cholesterol [β 0.05(0.03-0.08), P < .0001 and β 0.05(0.03-0.08), P < .0001, respectively]. Total cholesterol was significantly higher in children and adolescents with mild SCH compared with euthyroid children (4.43 ± 1.14 mmol/L vs 4.2 ± 0.85 mmol/L, P = .0005). Similarly, non-HDL cholesterol level was also higher in children with mild SCH relative to euthyroid children (3.08 ± 1.14 mmol/L vs 2.91 ± 0.8 mmol/L, P = .001). The adjusted odds ratio of having elevated total cholesterol and elevated non-HDL cholesterol was greater in children with mild SCH compared with euthyroid children (OR 1.88, 95% CI; 1.28-...Continue Reading

References

Mar 1, 2000·Archives of Internal Medicine·G J CanarisE C Ridgway
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Anne R Cappola, Paul W Ladenson
Feb 11, 2005·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·M Paoli-ValeriG Arata-Bellabarba
Jul 25, 2007·Archives of Internal Medicine·Giorgio IervasiAlessandro Pingitore
Sep 29, 2007·Thyroid : Official Journal of the American Thyroid Association·Leonidas H Duntas, Leonard Wartofsky
Nov 10, 2007·Endocrine Reviews·Bernadette Biondi, David S Cooper
Feb 26, 2009·The Journal of Clinical Endocrinology and Metabolism·Liora LazarJoseph Meyerovitch
Sep 23, 2010·JAMA : the Journal of the American Medical Association·Nicolas RodondiUNKNOWN Thyroid Studies Collaboration
Dec 1, 2010·Thyroid : Official Journal of the American Thyroid Association·Nicole S NaderSeema Kumar
Feb 5, 2011·European Journal of Endocrinology·Manuela CerboneMariacarolina Salerno
Jul 26, 2011·Clinical Biochemistry·Raman K MarwahaKuntal Bhadra
Nov 16, 2011·Pediatrics·UNKNOWN Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents, UNKNOWN National Heart, Lung, and Blood Institute
Sep 6, 2012·Endocrinology·Ira J GoldbergJoel R Ehrenkranz
May 21, 2014·The Journal of Clinical Endocrinology and Metabolism·Manuela CerboneMariacarolina Salerno
Dec 30, 2014·Journal of Clinical Research in Pediatric Endocrinology·Gönül ÇatlıAyhan Abacı
Apr 22, 2015·International Journal of Endocrinology·Aneta GawlikEwa Malecka-Tendera
Jan 14, 2016·Journal of Clinical Research in Pediatric Endocrinology·Emilio García-GarcíaAntonio Bonillo-Perales
Apr 14, 2016·European Journal of Endocrinology·Manuela CerboneMariacarolina Salerno
Nov 4, 2016·Nature Reviews. Endocrinology·Mariacarolina SalernoFilippo De Luca
Dec 23, 2016·Journal of Clinical Research in Pediatric Endocrinology·Edip UnalYusuf Kenan Haspolat

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Citations

Jan 11, 2020·Frontiers in Endocrinology·Rade VukovicJelena Vekic
May 28, 2020·International Journal of Clinical Practice·Sevinc Odabasi GunesFatma Nisanci Kilinc
Mar 27, 2020·International Journal of Environmental Research and Public Health·Małgorzata Karbownik-LewińskaAndrzej Lewiński

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